General Introduction

3 General introduction The search for natural resources for production and development of bioactive compounds of plant origin for environmental health and safety reasons is the main scope of this study. To achieve this aim, the work would focus on two approaches. Firstly, to obtain bioactive products, safe to our environment, from carnation stems. Secondly, to recycle the wasted plants; specially the infected ones, and utilize them as potential antimicrobial products of plant origin. Moreover, the resistance of microbes to synthetic compounds, promoted us to explore the synthesis of new potential antimicrobial compounds. Benzoxazinone compounds are an important class of heterocyclic compounds. They are used in many industrial, agricultural and clinical applications such as the benzoxazinone derivatives based which are compounds used as antiphlogistic drugs 1 . 4H-3,1-benzoxazin4-one compounds exhibit excellent inhibitory activities against the human leukocyte elastase 2 . Other benzoxazinone derivatives have been reported as starting materials for synthesis of quinazolin-4-ones derivatives. Pharmacologically, quinazolin-4-ones possess versatile type of biological activities, some of these are well known for their anticancer, antitubercular, antibacterial, antifungal, anti-HIV, antihelmintic, antiinflammatory and of antihypertensive activities. 3