{"title":"[纳洛酮对慢性十二指肠溃疡患者基底、经生长抑素抑制胃分泌的影响]。","authors":"M Lukin, K Markiewicz","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In 13 men with chronic duodenal ulcer disease effects of somatostatin and naloxone on basic gastric secretion were determined. Following intravenous somatostatin infusion a significant increase in basic gastric secretion was observed. Somatostatin also induced a significant increase in sodium concentration and a decrease in chloride concentration in the gastric juice. Total electrolyte and mucoprotein secretions changed proportionally to alterations in the gastric juice volume. Somatostatin-induced gastric secretion was unaffected by a single intravenous naloxone administration. In patients with chronic duodenal ulcer disease somatostatin and naloxone affect gastric secretion independently of each other.</p>","PeriodicalId":77539,"journal":{"name":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effect of naloxone on basal, by somatostatin inhibited stomach secretion in patients with chronic duodenal ulcer].\",\"authors\":\"M Lukin, K Markiewicz\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In 13 men with chronic duodenal ulcer disease effects of somatostatin and naloxone on basic gastric secretion were determined. Following intravenous somatostatin infusion a significant increase in basic gastric secretion was observed. Somatostatin also induced a significant increase in sodium concentration and a decrease in chloride concentration in the gastric juice. Total electrolyte and mucoprotein secretions changed proportionally to alterations in the gastric juice volume. Somatostatin-induced gastric secretion was unaffected by a single intravenous naloxone administration. In patients with chronic duodenal ulcer disease somatostatin and naloxone affect gastric secretion independently of each other.</p>\",\"PeriodicalId\":77539,\"journal\":{\"name\":\"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Effect of naloxone on basal, by somatostatin inhibited stomach secretion in patients with chronic duodenal ulcer].
In 13 men with chronic duodenal ulcer disease effects of somatostatin and naloxone on basic gastric secretion were determined. Following intravenous somatostatin infusion a significant increase in basic gastric secretion was observed. Somatostatin also induced a significant increase in sodium concentration and a decrease in chloride concentration in the gastric juice. Total electrolyte and mucoprotein secretions changed proportionally to alterations in the gastric juice volume. Somatostatin-induced gastric secretion was unaffected by a single intravenous naloxone administration. In patients with chronic duodenal ulcer disease somatostatin and naloxone affect gastric secretion independently of each other.
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