介电泳捕获环形交叉电极的模拟

A. Mansor, S. Ibrahim
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引用次数: 5

摘要

电场强度是电泳过程中捕获生物细胞的重要因素。本文设计了两种不同间距的环形交错电极(RIDE);300 μm ~ 500 μm,进行了建模和分析。利用有限元分析软件COMSOL Multiphysics对电极上产生的电场强度进行了分析。仿真结果表明,与对称RIDE设计相比,非对称RIDE设计产生了更高的电场。对称RIDE的正电场峰值平均值为16.1kV/m,不对称RIDE的正电场峰值平均值为19.9 kV/m。模拟还表明,与大间距相比,小间距产生的电场更大。这表明在不对称RIDE的最小距离上可以预测更好的细胞吸引力。捕获的细胞可用于研究特定细胞的细胞间或细胞内相互作用,例如通过阻抗传感形成集成的deep -impedance生物传感器。
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Simulation of ring interdigitated electrode for dielectrophoretic trapping
Electric field intensity is important in trapping biological cells during dielectrophoresis (DEP). In this paper, two designs of ring interdigitated electrode (RIDE) with varied spacing between electrodes; 300 μm to 500 μm, were modelled and analyzed. Analysis was done using finite element analysis software, COMSOL Multiphysics to study the intensities of electric fields generated on the electrodes. Simulation results show that higher electric fields are generated by the asymmetrical RIDE compared to the symmetrical RIDE design. The average value of positive electric fields peaks for symmetrical RIDE is 16.1kV/m and 19.9 kV/m for asymmetrical RIDE. Simulations also revealed that higher electric field were generated on smaller spacing compared to larger one. This suggested that better cellular attraction can be predicted on smallest distance of asymmetrical RIDE. Trapped cells can later be used to study the intercellular or intracellular interactions of the specific cells, such as through impedance sensing to form an integrated DEP-impedance biosensor.
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