内源性大麻素系统在系统毒性中的作用

General, Applied and Systems Toxicology Pub Date : 2011-09-15 DOI:10.1002/9780470744307.GAT206

C. Pistos, S. Theocharis

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引用次数: 0

摘要

在过去的20年里，关于内源性大麻素系统的调节及其对疾病病理生理的影响的科学知识有了显著的提高。大麻素受体、其主要内源性配体(花生四烯酰基乙醇酰胺和2-花生四烯酰基甘油)的表达以及相关酶水平在不同疾病状态下的变化已被报道，表明它们具有重要的调节作用。选择性靶向内源性大麻素系统的合成化合物的药理作用，建立了内源性大麻素与几种疾病进展之间的因果关系。在这篇综述中，内源性大麻素系统调节的重要性以及导致疾病或靶器官毒性的潜在途径的各个方面进行了报道。关键词:内源性大麻素;叫花生四烯酸乙醇胺;2-arachidoylglycerol;系统毒性;大麻素受体;免疫系统;炎症;肝纤维化;I / R

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Role of the Endocannabinoid System in Systems Toxicity

The scientific knowledge regarding the modulation of the endogenous cannabinoid system and its effect on disease pathophysiology has been significantly improved in the last 20 years. Alterations in the expression of cannabinoid receptors, their main endogenous ligands (arachidonoylethanolamide and 2-arachidonoylglycerol), and related enzyme levels have been reported in different disease states, suggesting their important regulatory role. The pharmacological effects of synthetic compounds that selectively target the endocannabinoid system, established cause-effect relationships between endocannabinoids and the progress of several disorders. In this review, the importance of endocannabinoid system modulation and also the aspects of the underlying pathways leading to disease or target organ toxicity are reported. Keywords: endocannabinoids; anandamide; 2-arachidoylglycerol; system toxicity; cannabinoid receptors; immune system; inflammation; fibrosis; I/R

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General, Applied and Systems Toxicology

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