兔实验性血管痉挛时动脉壁功能损伤的两项指标与不可逆收缩的时间过程平行。

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158859
P Vorkapic, J A Bevan, R D Bevan
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引用次数: 15

摘要

自体血液置于基底动脉周围引起血管造影狭窄,呈双相时间过程。动脉内注射罂粟碱可逆转第一阶段;第二种表现出越来越多的变窄成分,这是罂粟碱抗性的。体外研究表明,血管变得越来越僵硬,产生主动张力的能力减弱,对血管收缩剂和血管舒张剂的反应减弱。血管造影狭窄的罂粟碱抵抗成分(体内)可能与收缩性丧失和动脉壁刚度增加(体外)直接相关。
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Two indices of functional damage of the artery wall parallel the time course of irreversible narrowing in experimental vasospasm in the rabbit.

Autologous blood placed around the basilar artery caused angiographic narrowing with a biphasic time course. The first immediate phase was reversed by intraarterial papaverine; the second exhibited an increasing component of narrowing which was papaverine-resistant. In vitro studies showed that vessels became increasingly stiffer, less capable to develop active tone, and less responsive to vasoconstrictors and vasodilators. The papaverine-resistant component of angiographic narrowing (in vivo) could be directly correlated with loss of contractility and increased artery wall stiffness (in vitro).

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