经络在脑循环中的发展。

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158860
P Coyle, D D Heistad
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引用次数: 94

摘要

大脑中动脉(MCA)突然闭塞在正常血压的大鼠增加血流量通过吻合分支进入闭塞动脉的领土。MCA闭塞后3周,脑前支吻合口管腔直径增加50%以上。闭塞一个月后,血流及闭塞MCA区域的血流量储备恢复到正常水平。在卒中易发自发性高血压大鼠(SHRSP)中,吻合口明显变窄,通过吻合口的血流量比正常大鼠少。在SHRSP中,组织梗死总是发生在闭塞的MCA区域。我们认为吻合口的管腔宽度是血流进入闭塞动脉区域的主要决定因素,也是侧支循环保护组织免于梗死的主要决定因素。
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Development of collaterals in the cerebral circulation.

Sudden occlusion of the middle cerebral artery (MCA) in normotensive rats increases blood flow through anastomosing branches into the territory of the occluded artery. Three weeks after MCA occlusion, anastomoses to anterior cerebral branches are increased by more than 50% in luminal diameter. One month after MCA occlusion, blood flow and blood flow reserve to the territory of the occluded MCA are returned to normal levels. In stroke-prone spontaneously hypertensive rats (SHRSP), the anastomoses are significantly narrower and blood flow through the anastomoses is less than in normotensive rats. Tissue infarction invariably develops in the territory of the occluded MCA in SHRSP. We propose that the luminal width of the anastomosis is a major determinant of blood flow into the territory of the occluded artery and of the amount of tissue protected from infarction by collateral circulation.

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