{"title":"[小鼠有丝分裂或β -肾上腺素能刺激t淋巴细胞后腺苷酸环化酶活性细胞内定位的组织化学研究]。","authors":"D Paukstat, W Schulze, A Henkel, C Hückel","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The role of AC at the beginning of an immune response is not fully understood until now. Using the specific substrate AMP-PNP we could show AC-activity in ConA-stimulated murine spleen lymphocytes histochemically. In contrast to beta-adrenergic stimulation (by Isoproterenol) ConA-induced AC-activity was found not only at the cell membrane and the nuclear membrane but also at some structures of the Golgi apparatus of the cells. The difference in AC-activity after beta-adrenergic or mitogenic stimulation is discussed.</p>","PeriodicalId":7505,"journal":{"name":"Allergie und Immunologie","volume":"37 1","pages":"23-30"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Histochemical investigations of the intracellular localization of adenylate cyclase activity after mitogenic or beta-adrenergic stimulation of T-lymphocytes of the mouse].\",\"authors\":\"D Paukstat, W Schulze, A Henkel, C Hückel\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The role of AC at the beginning of an immune response is not fully understood until now. Using the specific substrate AMP-PNP we could show AC-activity in ConA-stimulated murine spleen lymphocytes histochemically. In contrast to beta-adrenergic stimulation (by Isoproterenol) ConA-induced AC-activity was found not only at the cell membrane and the nuclear membrane but also at some structures of the Golgi apparatus of the cells. The difference in AC-activity after beta-adrenergic or mitogenic stimulation is discussed.</p>\",\"PeriodicalId\":7505,\"journal\":{\"name\":\"Allergie und Immunologie\",\"volume\":\"37 1\",\"pages\":\"23-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Allergie und Immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Allergie und Immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Histochemical investigations of the intracellular localization of adenylate cyclase activity after mitogenic or beta-adrenergic stimulation of T-lymphocytes of the mouse].
The role of AC at the beginning of an immune response is not fully understood until now. Using the specific substrate AMP-PNP we could show AC-activity in ConA-stimulated murine spleen lymphocytes histochemically. In contrast to beta-adrenergic stimulation (by Isoproterenol) ConA-induced AC-activity was found not only at the cell membrane and the nuclear membrane but also at some structures of the Golgi apparatus of the cells. The difference in AC-activity after beta-adrenergic or mitogenic stimulation is discussed.
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