磁性纳米流体温度随MNPs浓度及扩散的分布

M. Mohammadzadeh, E. Rahmanian, Shima Tabakh, A. Mohammadzadeh
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引用次数: 3

摘要

分布率。磁性纳米流体热疗是一种调节和优化温度的方法,但在实际应用中存在很大的挑战。磁性纳米颗粒在肿瘤中通过磁线圈产生的热量与颗粒的分散、频率、磁场强度和组织的性质密切相关。因此,将磁性纳米颗粒注射到肿瘤组织中,在高振幅和高频率的交变磁场作用下,肿瘤组织温度升高,从而可能导致癌细胞的破坏。在本研究中,为了模拟实验不同部位的磁场强度,并求解传热方程,采用了COMSOL Multiphysics的有限元方法。然后,为了验证我们的模型,使用实验装置测量了琼脂糖凝胶中两种不同纳米流体浓度的温度分布,分别用于分散和浓缩注射。仿真结果与实验结果进行了比较,验证了模型的准确性。结果表明,凝胶不同部位的磁场不相同,但差异不显著。两种纳米流体在分散注入和浓缩注入中的温度分布都表现为三次多项式函数的行为。与分散注射相比,浓缩注射温度更高
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Magnetic Nanofluid Temperature Distribution with Different Concentrations and Diffusion of MNPs
distribution, rate. Hyperthermia therapy using magnetic nanofluid is one method to regulate and optimize temperature, which is a substantial challenge in practice. The generated heat through the magnetic coil using magnetic nanoparticles in the tumor is closely associated with the dispersion of particles, frequency, magnetic field intensity, and the property of the tissue. Therefore, with magnetic nanoparticles injected into tumor tissue and subjects to an alternating magnetic field with high amplitude and frequency, tumor tissue temperature rises, which could lead to destroying cancer cells. In this study, to simulate the magnetic field intensity at different parts of the experiment and to solve heat transfer equation, a finite element method using COMSOL Multiphysics has been used. Then, to verify our model, an experimental setup was used to measure temperature distribution in an agarose gel with two different nanofluid concentrations for dispersed and concentrated injections. Simulation results have been compared with experimental ones to show the model's accuracy. Results indicate that the magnetic field in different parts of the gel is not the same, but the differences are insignificant. Temperature distribution for both types of nanofluid in dispersed and concentrated injections has a behavior like a polynomial function with a degree of three. Compared to dispersed injection, a higher temperature is observed in concentrated
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