Minimal invasive surgery (MIS) with and without advanced platelet-rich fibrin (PRF) in treatment of localized periodontitis stage III grade B

Objectives : The objective of this study was to evaluate and compare between minimal invasive surgical treatment (MIST) with and without platelet-rich fibrin (PRF) in patient with localized periodontitis stage III grade B. Subjects and methods : A total of twenty two patients were 10 females and 12 male in this study. The study was designed as Randomized, controlled, parallel, single- blinded clinical trial. The patients were divided into two groups using split mouth technique. The study protocol involved a screening appointment, initial phase therapy, surgical therapy, all patients followed up for 6 months. The defect-associated interdental papilla was surgically approached with modified papilla preservation technique MPPT Cortellini et al. 1995. Results : The results of the present study showed similar reductions in PPD at the deepest site in both groups after 6 months of follow-up (PPD, 3.18±1.12 mm in the MIS without PRF group and 3.23±0.61 mm in the M-MIST with PRF group), for CAL gain a higher mean value was recorded in the MIS with PRF group, with a mean 2.13±0.77, in comparison to 1.90±0.94 in control group (MIS without PRF), with no significant difference. Conclusions : The platelet-rich fibrin when combined with minimally invasive surgery, produces better outcomes compared to the open flap debridement alone.