胃肠道离体组织多波长偏振法提高肿瘤诊断价值

D. Ivanov, Tsanislava Genova-Hristova, E. Borisova, L. Nedelchev, D. Nazarova
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引用次数: 8

摘要

组织偏振法在医学上的应用主要是为了对健康组织和肿瘤组织进行非侵入性和高灵敏度的区分。这种快速,相对便宜的方法可能对医生更好的组织学诊断有用。虽然,最具挑战性的目标是将组织偏振光学系统应用于体内测量,但最初必须使用离体组织学样品,幻影等来优化光学系统。本文利用市售偏振光计检测和处理的444 nm、488 nm、514 nm、594 nm和635 nm波长的偏振光,对下消化道组织学样品的偏振参数进行了研究。我们的实验结果表明,对于所有使用的结肠样品,最佳波长选择是635 nm。实验中使用了圆偏振光,发现与线偏振光相比,它能经受更多的散射事件。此外,圆偏振光携带有关电场两个正交分量(Ex和Ey)之间相位差的附加信息,并且在反射的情况下,极化的入射状态经历了其螺旋度的一个ip。通过这种方法,可以更好地检测组织中与组织结构异常相关的组织学变化。此外,多波长偏振分析可以为未来的体内实施提供更好的见解,并且本研究中提出的离体生物样品的结果有助于更好地基于光学测量的区分,适用于肿瘤检测。
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Multiwavelength polarimetry of gastrointestinal ex vivo tissues for tumor diagnostic improvement
The implementation of tissue polarimetry in medicine arises mainly for the need of non-invasive and highly sensitive discrimination between healthy and tumor tissues. This fast, relatively cheap method may be useful for better histological diagnostics by the physicians. Although, the most challenging goal is to apply tissue polarimetric optical system for in vivo measurements, initially one have to optimize the optical system using ex vivo histological samples, phantoms and etc. This paper is focused on the polarimetric parameters from lower gastrointestinal tract histological samples, by using polarized light with several wavelengths, namely 444 nm, 488 nm, 514 nm, 594 nm and 635 nm, detected and processed by commercially available polarimeter. Our experimental results reveal the best wavelength choice in favor of 635 nm for all colon samples used. Light with circular polarization was used in the experiments, as found to survive more scattering events, compared to linearly polarized light. Furthermore, circularly polarized light carries additional information about the phase difference between the two orthogonal components of the electric field (Ex and Ey) and in the case of reflection, the incident state of polarization undergoes a ip of its helicity. By this way, a better detection of histological changes in tissues, related to abnormal tissue structure can be made. Furthermore, the multiwavelength, polarimetric analysis may provide better insight for future in vivo implementation and the results from the ex vivo biological samples presented in this study, contribute to better discrimination based on optical measurements, applicable for tumor detection.
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