组蛋白外泌体驱动的表观遗传调控:开创性的抗肿瘤和皮肤健康应用

Y. Ekta, Yadav Niket, Vanta Katherine, Yadav Jagjit S
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摘要

本文探讨了外泌体在皮肤护理中的应用及其在皮肤成纤维细胞和其他免疫调节细胞中修饰表观遗传变化的潜力。外泌体是纳米级的细胞外囊泡,通过在细胞间运输各种生物分子,如蛋白质、脂质和核酸,在细胞间通讯中起着至关重要的作用。它们由皮肤细胞释放,含有对皮肤健康至关重要的各种分子,如生长因子、细胞因子和细胞外基质蛋白。最近的研究表明,外泌体可以改变皮肤细胞的表观遗传变化,特别是组蛋白,它们有可能被用作各种皮肤疾病的治疗剂。本文讨论了外泌体在皮肤护理中的应用,以及它们在皮肤细胞响应环境因素时调节表观遗传变化的潜力,重点是组蛋白修饰。
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Exosome-driven epigenetic modulation of histone proteins: Pioneering anti-oncogenic and skin health applications
This article explores the use of exosomes in skin care and their potential for modifying epigenetic changes in fibroblasts and other immune regulatory cells of the skin. Exosomes are nanosized extracellular vesicles that play a vital role in intercellular communication by transporting various biomolecules such as proteins, lipids, and nucleic acids between cells. They are released by skin cells and contain various molecules that are essential for skin health, such as growth factors, cytokines, and extracellular matrix proteins. Recent studies have shown that exosomes can modify epigenetic changes in skin cells, particularly histones, and they have the potential to be used as a therapeutic agent in various skin disorders. This article discusses the use of exosomes in skin care and their potential for modulating epigenetic changes in skin cells in response to environmental factors, with a focus on histone modifications.
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