冠状造影检查患者动脉粥样硬化危险因素。3结果和评价组的妇女]。

J Baudysová, J Kvasnicka, P Zdánský, A Hlava, L Strnad
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摘要

本文对63例女性受试者进行了动脉粥样硬化危险因素发生与冠状图异常发生率的比较研究。作为一种异常冠状造影发现,阻塞超过50%的至少一个冠状动脉管腔估计。高脂蛋白血症(p < 0.001)和高血压(p < 0.05)的女性受试者冠状造影异常表现更为频繁。冠状造影阳性的女性显示总胆固醇水平明显升高(p < 0.05)。病理冠状图与糖苷代谢紊乱无相关性。特别有趣的是,在我们的研究中,女性中甘油代谢紊乱导致高脂蛋白血症的发生率高达15-16% (p < 0.001),而男性中只有1- 2% (p < 0.05)。这些结果支持了一些作者的观点,他们指出甘油代谢障碍和高脂血症之间的相互作用,估计女性甘油代谢障碍是冠状动脉粥样硬化比男性更重要的危险因素。我们的研究结果证实了女性动脉粥样硬化危险因素的特异性。据此,高脂血症和高血压的重要性被认为是动脉粥样硬化发生的最重要的危险因素。在男性和女性中,通过共同的方法实施缺血性心脏病的一级和二级预防原则。
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[Atherosclerosis risk factors in patients examined by coronarography. III. Results and evaluation of the group of women].

The occurrence of atherosclerosis risk-factors has been studied in comparison with the rate of abnormal coronarogram in 63 female subjects. As an abnormal coronarographic finding the obstruction of more than 50% lumen of at least one of coronaries was estimated. Female subjects with hyperlipoproteinemia (p less than 0.001) and hypertension (p less than 0.05) showed significantly more frequent abnormal coronarographic findings. Coronarographically positive women revealed significantly higher levels of total cholesterol (p less than 0.05). No relationship was detected between the pathological coronarogram and glycide metabolic disorders. Of particular interest is a fact that the disorders of glycide metabolism are conditioning the occurrence of hyperlipoproteinemia in women of our group as far as 15-16% (p less than 0.001), whereas in men only as 1-2 % (p less than 0.05). These results are supporting the opinion of those authors who point on the interaction between the disorders of glycide metabolism and hyperlipidemia estimating disorders of glycide metabolism in women to be more significant risk-factor of coronary atherosclerosis than in men. Our findings are confirming specificity of profile of atherosclerotic risk-factors in women. In accord with them, the importance of hyperlipidemia and hypertension is estimated to be the most significant risk of atherogenesis. The implementation of principles of primary and secondary prevention of ischemic heart disease is carried through the common approaches in both men and women.

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