氨基酸诱导胰岛素从灌注大鼠胰腺释放。苯丙氨酸和酪氨酸的影响。

Acta physiologica Polonica Pub Date : 1990-11-01

P Maćkowiak

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摘要

研究了L、D苯丙氨酸和L酪氨酸对灌注大鼠胰腺胰岛素释放的影响。研究发现，在d -葡萄糖存在的情况下，这三种氨基酸都能刺激胰岛素分泌。在l -酪氨酸存在或不存在的情况下，从灌注液中去除l -苯丙氨酸后，胰岛素释放的二次上升(“关闭反应”)被注意到。D-Phe和L-Tyr都没有出现这种现象。

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Amino acid--induced insulin release from the perfused rat pancreas. The influence of phenylalanine and tyrosine.

The effects of L or D phenylalanine and L tyrosine on insulin release from the perfused rat pancreas were investigated. It was found that in the presence of D-glucose, all three amino-acids stimulate insulin secretion. After L-Phe had been removed from perfusate in the presence or absence of L-Tyr, the secondary rise of insulin release (an "off response") was noticed. This phenomenon did not follow to either D-Phe or L-Tyr.

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Acta physiologica Polonica

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