0.1%他克莫司软膏治疗儿童局限性白癜风:一项前瞻性研究

Hussein Odeibat, Mohammad Al-Tawara
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摘要

目的:分析诊断和治疗过程中出现困难的颈部肿块的手术干预措施,并探讨解决建议。研究设计:这是一项回顾性研究,对2006年至2013年间因颈部肿块接受手术的11例患者进行了评估。结果:平均随访时间为25.70±28.36个月(最短6个月~最长84个月)。11例患者(7名女性,4名男性)的平均年龄为47.00±15.74岁(最小16岁,最大63岁)。经组织病理学检查,3例患者为原发不明的转移性鳞状细胞癌,4例患者为良性副神经节瘤,2例患者为神经鞘瘤,1例患者为伯基特淋巴瘤,1例患者为结核性淋巴结炎。3例颈动脉球囊手术患者中2例发生颈动脉破裂。其中,一名患者进行了移植物修复,而另一名患者发生了偏瘫。患者接受手术,初步诊断为巨大迷走神经副神经节瘤死于术后24小时肺血栓栓塞。伯基特淋巴瘤患者在颈部活检时发现颈内静脉破裂,导致颈部探查。术中平均失血量为695.45±739.41 (min.100 max.2200) cc。结论:在诊断过程中,最具挑战性的问题是在建立椎旁肌肉或主要血管结构方面的放射资料失败。在治疗过程中,颈内动脉和颈内静脉意外破裂的控制相当困难。
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Use of Tacrolimus ointment 0.1% for treatment of childhood localized Vitiligo : A prospective Study
Objective: The aim of this study is to analyze surgical interventions performed for neck masses causing difficulty during diagnosis and treatment process as well as to discuss recommendations of solution. Study design: This is a retrospective study in which 11 patients who underwent surgery due to a neck mass between 2006 and 2013 were evaluated. Results: Mean follow-up was 25.70±28.36 (min .6 – max .84) months. The mean age was 47.00±15.74 (min.16 max.63) years in 11 patients (7 women, 4 men) included in the study. By the histopathological evaluation, it was found that there was a metastatic squamous cell carcinoma of unknown primary in 3 patients, a benign paraganglioma in 4 patients, a schwannoma in 2 patients, Burkitt lymphoma in one patient and tuberculosis lymphadenitis in one patient. Carotid rupture occurred in 2 of 3 patients who underwent surgery for glomus caroticum. Of these, graft repair was performed in one patient while hemiplegia developed in the other. The patient who underwent surgery with an initial diagnosis of giant vagal paraganglioma died on the postoperative hour 24 due to pulmonary thromboembolism. Internal jugular vein rupture developed in the patient with Burkitt lymphoma during neck biopsy, leading neck exploration. Mean blood loss was estimated as 695.45±739.41 (min.100 max.2200) cc during surgery. Conclusion: During the diagnostic process, the most challenging issue had been failure of radiological data in terms of establishing paravertebral muscles or major vascular structures. During treatment process, the control of unexpected ruptures in internal carotid and internal jugular veins had been rather difficult.
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