恶性淋巴瘤患者细胞抑制剂治疗所致口腔黏膜炎程度的评价

Adrian Muică, Florentin-Daniel Berneanu, L. Hănțoiu, Dorner Kinga, Adriana-Elena Crăciun
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引用次数: 0

摘要

摘要简介:口腔黏膜炎以口腔黏膜炎症、溃疡、角状口唇炎伴上颌面区疼痛为特征,是接受细胞抑制剂治疗的患者的症状,影响75%以上的高危患者。材料与方法:从182例恶性血液病患者中选取2013年7月至2016年6月期间在雷乌斯县1号医学诊所血液科诊断为恶性淋巴瘤并接受治疗的患者59例,对数据观察表中的数据进行分析。这项研究是回顾性的。结果:在采用上述抑细胞方案治疗的患者组中,我们发现CVP +利妥昔单抗方案经常引起1级和2级口炎,没有患者发生3级和4级口炎。CHOP +利妥昔单抗治疗方案共80例出现1、2级口炎并发症,1级多见,无2、4度口炎。III级口炎发生在两例CHOP-Bleo带。在肿瘤血液学医学多学科的背景下引入口腔医学是非常必要的,因为化疗的口腔并发症的严重程度会导致治疗方案的妥协,减少剂量甚至停止治疗。结论:恶性血液病在口腔疾病中占很大比例,其中以非霍奇金恶性淋巴瘤和霍奇金恶性淋巴瘤的严重程度最高。口腔炎,又称药物引起的龈毒性口炎,是一种急性口腔并发症,整个口腔出现红斑和水肿。在细胞抑制疗法之后,牙医在口腔病变的诊断、预防和治疗中的作用是极其重要的。
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Assessment of oral mucositis degree due to cytostatic treatment in patients with malignant lymphomas
Abstract Introduction: Oral mucositis characterized by inflammation of the oral mucosa, ulcers, angular cheilitis, accompanied by pain in the maxillary facial area are symptoms of patients who have undergone cytostatic treatment, affecting over 75% of high-risk patients. Material and methods: From the total of 182 patients with hematological malignancies, we selected 59 patients, diagnosed with malignant lymphomas and treated at the Hematology Department of the Medical Clinic 1 in Tîrgu Mureș, between July 2013 and June 2016, analyzing the data in the data observation sheets. The study is a retrospective one. Results: In the group of patients studied, who were treated based on the aforementioned cytostatic plans, we found that the CVP + Rituximab plan frequently causes 1st and 2nd class stomatitis, with no patients with 3rd and 4th class stomatitis. The CHOP + Rituximab therapy plan in a total of 80 applications had complications of 1st and 2nd class stomatitis, much more frequent 1st class without stomatitis of 2nd and 4th degree. Grade III stomatitis occurs in two cases in the CHOP-Bleo belts. Introducing dental medicine in the context of medical multidisciplinarity in oncology hematology is a real necessity because the oral complications of chemotherapy treatments by their severity can lead to compromise of the treatment protocol by reducing the doses or even stopping the treatment Conclusions: Malignant hemopathies represent a significant percentage in dental disorders, and among them, the maximum severity belongs to the non-Hodgkin and Hodgkin malignant lymphomas. Stomatitis, also called gingivotoxic stomatitis caused by medication, is an acute oral complication, with erythema and edema of the entire oral cavity. The role of the dentist in the diagnosis, prevention and treatment of oral lesions, following the cytostatic therapy, is extremely important.
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