AML合作群体的顺序决策策略研究。

A Heinecke, M C Sauerland, T Büchner
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引用次数: 1

摘要

1985年进行的研究显示目前两种疗法都没有明显的优势。在1981年的研究中,随机化在161次随机化后被顺序程序终止。如果采用相同的α和β,但样本量固定,则至少需要200名患者,每种疗法100名。所以在这种情况下,使用顺序过程节省了大约40个随机化。
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Sequential decision strategy of the AML Cooperative Group studies.

The ongoing 1985 studies are showing at present no clear advantage for either therapy. In the 1981 study, randomization was terminated by the sequential procedure after 161 randomizations. A test with the same alpha and beta but fixed sample size would have required at least 200 patients, 100 for each therapy. So in this case the use of the sequential procedure saved about 40 randomizations.

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