{"title":"人受体p2y12复合物与r-138727分子的分子模拟","authors":"A. Morozova, A. Bakunovich","doi":"10.46646/sakh-2021-2-76-79","DOIUrl":null,"url":null,"abstract":"The leading cause of human death throughout the world is atherothrombosis of various localization. The key point in the fight against this pathology is the appointment of antiplatelet agents. These drugs differ from each other in the mechanism of inhibiting platelet activity. Prasugrel, an antagonist of the thienopyridine class, is a potent inhibitor of platelet activation and aggregation mediated by platelet ADP receptors of the P2Y12 class.","PeriodicalId":385455,"journal":{"name":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"MOLECULAR MODELING OF THE P2Y12 COMPLEX OF HUMAN RECEPTOR WITH R-138727 MOLECULE\",\"authors\":\"A. Morozova, A. Bakunovich\",\"doi\":\"10.46646/sakh-2021-2-76-79\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The leading cause of human death throughout the world is atherothrombosis of various localization. The key point in the fight against this pathology is the appointment of antiplatelet agents. These drugs differ from each other in the mechanism of inhibiting platelet activity. Prasugrel, an antagonist of the thienopyridine class, is a potent inhibitor of platelet activation and aggregation mediated by platelet ADP receptors of the P2Y12 class.\",\"PeriodicalId\":385455,\"journal\":{\"name\":\"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-05-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46646/sakh-2021-2-76-79\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY Part 2","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46646/sakh-2021-2-76-79","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
MOLECULAR MODELING OF THE P2Y12 COMPLEX OF HUMAN RECEPTOR WITH R-138727 MOLECULE
The leading cause of human death throughout the world is atherothrombosis of various localization. The key point in the fight against this pathology is the appointment of antiplatelet agents. These drugs differ from each other in the mechanism of inhibiting platelet activity. Prasugrel, an antagonist of the thienopyridine class, is a potent inhibitor of platelet activation and aggregation mediated by platelet ADP receptors of the P2Y12 class.
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