Gabor域光学相干显微镜

J. Rolland, P. Meemon, S. Murali, Apurva Jain, Nicolene Papp, K. P. Thompson, Kye S. Lee
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引用次数: 22

摘要

光学相干显微镜(OCM)是一种新兴的技术,能够在微米尺度上对生物组织进行深度切片。在本文中,我们提出了一种发展中的技术,我们称之为Gabor域光学相干显微镜(GD-OCM),其创新之处有两个方面:(1)动态聚焦光学探针的高横向分辨率光学设计,无运动部件,在2mm的全视场和2mm的成像深度上提供了目前3 μm的不变分辨率;(2)一种采集方案(使用探针),该方案能够执行自动数据融合,以体内速度在整个样品深度呈现焦内高分辨率图像。
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Gabor domain optical coherence microscopy
Optical Coherence Microscopy (OCM) is an emerging technology capable of depth sectioning of biological tissue at the micrometer scale. In this paper, we propose a developing technology we call Gabor Domain Optical Coherence Microscopy (GD-OCM), whose innovation is two folds: (1) A high lateral resolution optical design of a dynamic-focusing optical probe with no moving parts, which provides an invariant resolution of currently 3 μm across a 2mm full-field of view and 2mm imaging depth by design; (2) An acquisition scheme (using the probe) that is capable of performing automatic data fusion to render an in-focus high resolution image throughout the depth of sample at in vivo speeds.
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