阻力动脉张力受压力和流量的独立影响。

Blood vessels Pub Date : 1990-01-01 DOI:10.1159/000158811
J A Bevan, J L Garcia-Roldan, E H Joyce
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引用次数: 25

摘要

兔阻力动脉对压力和血流的反应已经使用两种体外技术进行了检测——当等距安装在肌图上时,以及当使用自动记录直径的视频系统进行灌注时。后一种方法允许独立控制压力和流量。在这种情况下,研究了三种反应;肌源性收缩和依赖血流的收缩和扩张。所有反应均发生在内皮去除后,吲哚美辛(10(-60 M))对其没有影响。压力效应和流量效应可分别引起,且具有不同的离子碱。肌源性反应的有效刺激是拉伸,而血流的有效刺激可能是剪切应力。这些作用的机械换能器是不同的,它们位于血管平滑肌细胞或其周围的细胞外基质中。
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Resistance artery tone is influenced independently by pressure and by flow.

The responses of rabbit resistance arteries to pressure and flow have been examined using two in vitro techniques--when mounted isometrically in a myograph and when perfused using a video system that automatically registers diameter. The latter approach allows pressure and flow to be independently controlled. Under such circumstances three responses were studied; myogenic contraction and flow-dependent constriction and dilation. All responses occurred after endothelium removal and were unaffected by indomethacin (10(-60 M). The pressure and flow effects can be elicited separately and have different ionic bases. The effective stimulus for the myogenic response is stretch and that for flow is presumably shear stress. The mechano-transducers for these effects are different and are located either in the vascular smooth muscle cells or their surrounding extracellular matrix.

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