[Modification of immunotherapy with insect venom].

Allergic side effects give rise to a modification of the immunotherapy. Variation of the injection protocol and/or prophylactic application of antihistamines are successful in many patients. Combined active and passive immunotherapy is helpful only in a part of the remaining cases; this therapy is expensive and practicable only in few specialized clinics. Up to date a superior tolerance together with an at least equal efficacy as compared to conventional aqueous extracts has not been demonstrated either for aluminium precipitated or for chemically modified extracts.