β -2微球蛋白在口腔扁平苔藓中的表达。

Zeitschrift fur Hautkrankheiten Pub Date : 1990-09-01

M Simon, N Vigneswaran

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引用次数: 0

摘要

在15例口腔扁平苔藓(OLP)患者中，我们对受累和未受累的口腔黏膜进行了活检。免疫组织化学研究了标本中β 2-微球蛋白(β 2-M)的表达。与未受累的粘膜相比，我们证实在OLP病变的角化细胞中明确表达β 2-M。我们的研究结果与自身免疫过程参与OLP发病机制的假设一致。

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[Beta-2-microglobulin expression in oral lichen planus].

In 15 patients suffering from oral lichen planus (OLP), we took biopsies of both involved and noninvolved oral mucosa. The specimens were immunohistochemically studied with regard to the expression of beta-2-microglobulin (beta 2-M). In contrast to noninvolved mucosa, we proved definite beta 2-M expression in keratinocytes from OLP lesions. Our findings agree with the assumption that an autoimmunological process is involved in the pathogenesis of OLP.

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