上睑下垂显示Tolosa Hunt综合征1例报告

Mtalai Naoual, Hamdani Hind, Chahir Roukaya, Daghouj Ghizlane, El Maaloum Loubna, Allali Bouchra, El Kettani Asmaa
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摘要

托罗萨-亨特综合征是一种病因不明的罕见疾病,临床表现为单侧眼眶疼痛和眼麻痹。我们报告一例48岁的女性,她在2天内出现急性上眼睑下垂,之前有眶后疼痛,没有其他神经功能障碍。观察单侧第3、4、6脑神经麻痹。紧急脑磁共振成像(MRI)显示海绵窦不对称,右侧海绵窦呈椭圆形,明显增厚。MRI未见海绵体血栓及颅内病变征象。诊断为三手性甲状腺肿,并开始皮质类固醇治疗,症状完全改善。海绵窦的非特异性炎症导致了托洛萨-亨特综合征。复视和上睑下垂是神经麻痹的结果。三步走治疗具有挑战性,需要多学科合作,包括眼科医生、神经科医生和神经放射科医生。它的特点是对类固醇治疗反应迅速。
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Ptosis Revealing A Tolosa Hunt Syndrome: A Case Report
Tolosa-Hunt Syndrome is a rare condition with an undetermined etiology that manifests clinically as unilateral orbital pain and ophthalmoplegia. We report the case of a 48-year-old female who developed acute eight upper lid ptosis within 2 days, which was preceded by retro-orbital pain without other neurological deficits. Unilateral 3d, 4th and 6th cranial nerves palsy were observed. An emergent brain magnetic resonance image (MRI)  revealed a cavernous sinus asymmetry, with an oblong, well-defined thickening of the right cavernous sinus. The MRI revealed no signs of cavernous thrombosis nor intracranial lesion. THS was diagnosed, and corticosteroid treatment was initiated, with complete improvement in symptoms.  A non-specific inflammation of the cavernous sinus causes the Tolosa-Hunt syndrome. Diplopia and ptosis can occur as a result of nerve paralysis. THS management is challenging and should be multidisciplinary, involving ophthalmologists, neurologists, and neuroradiologists. It is characterized by rapid response to treatment with steroids.
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