Hyunkyu Moon, T. Comi, Sage J. B. Dunham, B. Kwon, J. Sweedler, W. King
{"title":"原子力显微镜质谱分析中的微尺度输运物理和改进的采样效率","authors":"Hyunkyu Moon, T. Comi, Sage J. B. Dunham, B. Kwon, J. Sweedler, W. King","doi":"10.1109/TRANSDUCERS.2017.7993978","DOIUrl":null,"url":null,"abstract":"This paper reports improvements of atomic force microscopy (AFM) mass spectrometry (MS), in which ∼1 attoliter of analyte is desorbed by a heated AFM cantilever tip and analyzed with a mass spectrometer. Decoupling the AFM sampling apparatus from the MS system enabled analysis of the microscale transport physics independent of analyte ionization efficiency. Using this approach, we find that the transport efficiency is governed by the air velocity during sampling, and not mass flow rate as reported in the literature. We also find that an unheated sampling tube results in higher efficiency compared to a heated tube. Optimization of the transport parameters improved the system efficiency by 2.5-fold over the state of the art.","PeriodicalId":174774,"journal":{"name":"2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microscale transport physics during atomic force microscopy mass spectrometry and improved sampling efficiency\",\"authors\":\"Hyunkyu Moon, T. Comi, Sage J. B. Dunham, B. Kwon, J. Sweedler, W. King\",\"doi\":\"10.1109/TRANSDUCERS.2017.7993978\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This paper reports improvements of atomic force microscopy (AFM) mass spectrometry (MS), in which ∼1 attoliter of analyte is desorbed by a heated AFM cantilever tip and analyzed with a mass spectrometer. Decoupling the AFM sampling apparatus from the MS system enabled analysis of the microscale transport physics independent of analyte ionization efficiency. Using this approach, we find that the transport efficiency is governed by the air velocity during sampling, and not mass flow rate as reported in the literature. We also find that an unheated sampling tube results in higher efficiency compared to a heated tube. Optimization of the transport parameters improved the system efficiency by 2.5-fold over the state of the art.\",\"PeriodicalId\":174774,\"journal\":{\"name\":\"2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/TRANSDUCERS.2017.7993978\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/TRANSDUCERS.2017.7993978","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Microscale transport physics during atomic force microscopy mass spectrometry and improved sampling efficiency
This paper reports improvements of atomic force microscopy (AFM) mass spectrometry (MS), in which ∼1 attoliter of analyte is desorbed by a heated AFM cantilever tip and analyzed with a mass spectrometer. Decoupling the AFM sampling apparatus from the MS system enabled analysis of the microscale transport physics independent of analyte ionization efficiency. Using this approach, we find that the transport efficiency is governed by the air velocity during sampling, and not mass flow rate as reported in the literature. We also find that an unheated sampling tube results in higher efficiency compared to a heated tube. Optimization of the transport parameters improved the system efficiency by 2.5-fold over the state of the art.