一种用于蛋白质相似性分析的序列分割方法

Fen Kong, Xuying Nan, P. He, Qi Dai, Yu-Hua Yao
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引用次数: 0

摘要

基于两种氨基酸分类的蛋白质序列的二维图形表示概述。介绍了将长序列划分为k段的方法(SSM),将蛋白质图划分为k段,并给出所有蛋白质曲线段的几何中心点作为蛋白质序列的描述符。它不仅可用于蛋白质的比较研究,而且可用于编码蛋白质结构的先天信息。最后,以一个简单的例子来强调新描述子在取自12个杆状病毒蛋白的蛋白质序列上的行为。
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A sequence-segmented method applied to the similarity analysis of proteins
A 2-D graphical representation of protein sequences based on two classifications of amino acids is outlined. The method of dividing a long sequence into k segments (SSM) is introduced, so protein graph is divided into k segments, geometrical center of the points for all protein curve segment is given as descriptors of protein sequences. It is not only useful for comparative study of proteins, but also for encoding innate information about the structure of proteins. Finally, a simple example is taken to highlight the behavior of the new descriptor on protein sequences taken from the 12 baculoviruse proteins.
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