双酚A二甲基丙烯酸酯对雄性小鼠生殖系统和生育能力的非单调效应导致受孕能力受损。

IF 3.2 4区 医学 Q1 Pharmacology, Toxicology and Pharmaceutics Toxicology Mechanisms and Methods Pub Date : 2024-03-01 Epub Date: 2023-11-15 DOI:10.1080/15376516.2023.2279723
Homa Darmani, Maysoon M A Alkhatib
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引用次数: 0

摘要

双酚A二甲基丙烯酸酯(Bisphenol A Dimethacrylate, Bis-DMA)是一种雌激素,可引起生殖道和神经内分泌轴的改变,从而影响动物的正常发育、成熟和受孕性能。我们研究了暴露于不同浓度双- dma 14周对雄性小鼠受孕性能的影响。采用双双dma(0、0.1 mg/L、1.0 mg/L、10 mg/L)对雄性小鼠进行饮水处理,观察双双dma对雄性小鼠生育能力、生殖器官重量、生殖激素水平、精子数量和睾丸组织学的影响。我们清楚地证明,雄性小鼠长期暴露于双双dma会对其生育和繁殖产生负面影响,导致精子数量显著减少,对血清LH和睾酮水平产生非单调效应,精囊重量增加,胚胎着床数量和存活胎儿数量减少,以及与双双dma处理的雄性交配的雌性胚胎吸收增加。此外,双- dma引起睾丸基础设施异常,萎缩的精管表现为上皮内空泡化和紊乱,生殖细胞丢失和脱落到管腔,以及细胞凋亡的存在。我们的数据表明,Bis-DMA通过干扰睾丸中正常的激素信号,诱导睾丸基础设施的变化,最终导致生殖功能和生育能力受损,从而对男性生育和生殖产生不利影响。
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Non-monotonic effects of Bisphenol A Dimethacrylate on male mouse reproductive system and fertility leads to impaired conceptive performance.

As an estrogenic agent, Bisphenol A Dimethacrylate (Bis-DMA) may incite alterations in both the reproductive tract and the neuroendocrine axis, and thus have the potential to affect the proper development, maturity and conceptive performance in animals. We investigated the consequences of 14 weeks of exposure to different concentrations of Bis-DMA on male mouse conceptive performance. Male mice were exposed to Bis-DMA (0, 0.1 mg/L, 1.0 mg/L or 10 mg/L) via drinking water, and the effects on fertility, reproductive organ weights, reproductive hormone levels, sperm counts and testicular histology were assessed. We clearly demonstrate that prolonged exposure of male mice to Bis-DMA negatively affects fertility and reproduction causing significant reductions in sperm counts, non-monotonic effects on serum LH and testosterone levels, increased seminal vesicle weights, lower number of embryonic implantations and viable fetuses, as well as, increased embryonal resorptions in females mated by Bis-DMA treated males. Furthermore, Bis-DMA caused abnormalities in testicular infrastructure with atrophic seminiferous tubules exhibiting intraepithelial vacuolization and disorganization, loss and shedding of germ cells into the lumen, and presence of apoptotic cells. Our data collectively suggest that Bis-DMA adversely affects male fertility and reproduction by interference with normal hormone signaling in the testis, inducing changes in testicular infrastructure and ultimately leading to impaired reproductive function and fertility.

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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
66
审稿时长
6-12 weeks
期刊介绍: Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.
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