两点Dixon和六点Dixon磁共振技术在肝脂肪变性的检测、定量和分级中的应用。

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING World journal of radiology Pub Date : 2023-10-28 DOI:10.4329/wjr.v15.i10.293
Mohamed Elfaal, Alanna Supersad, Craig Ferguson, Stephanie Locas, Florin Manolea, Mitchell P Wilson, Medica Sam, Wendy Tu, Gavin Low
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引用次数: 0

摘要

背景:肝脂肪变性是世界范围内非常普遍的问题。目的:评价二点和六点迪克森磁共振(MR)技术在肝脂肪变性的检测、定量和分级中的应用价值。方法:对62例疑似实质性肝病患者进行单中心回顾性研究。MR序列包括两点Dixon、六点Dixon、MR光谱(MRS)和MR弹性成像。将Dixon技术估计的脂肪分数(FF)与mrs质子密度FF (PDFF)进行比较。使用的统计检验包括皮尔逊相关和接受者工作特征。结果:Dixon技术的FF估计值与MRS-PDFF具有良好的相关性(≥0.95),并且在以下方面具有良好的准确性[受试者工作特征下面积(AUROC)≥0.95]:(1)检测脂肪变性;(2)重度脂肪变性分级(P < 0.001)。在铁超载时,由于混淆T2*效应,两点Dixon不能评估。6点Dixon与MRS-PDFF的FF估计显示,铁超载的中度相关性(0.82)与无铁超载的极好相关性(0.97)(P < 0.03)。当排除铁超载病例时,6点Dixon分级轻度脂肪变性的准确性提高(AUROC: 0.59至0.99)。Dixon技术与MRS-PDFF之间的极好相关性(> 0.9)在肝纤维化存在时没有改变(P < 0.01)。结论:Dixon技术对肝脂肪变性的评价令人满意,但也有例外。
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Two-point Dixon and six-point Dixon magnetic resonance techniques in the detection, quantification and grading of hepatic steatosis.

Background: Hepatic steatosis is a very common problem worldwide.

Aim: To assess the performance of two- and six-point Dixon magnetic resonance (MR) techniques in the detection, quantification and grading of hepatic steatosis.

Methods: A single-center retrospective study was performed in 62 patients with suspected parenchymal liver disease. MR sequences included two-point Dixon, six-point Dixon, MR spectroscopy (MRS) and MR elastography. Fat fraction (FF) estimates on the Dixon techniques were compared to the MRS-proton density FF (PDFF). Statistical tests used included Pearson's correlation and receiver operating characteristic.

Results: FF estimates on the Dixon techniques showed excellent correlation (≥ 0.95) with MRS-PDFF, and excellent accuracy [area under the receiver operating characteristic (AUROC) ≥ 0.95] in: (1) Detecting steatosis; and (2) Grading severe steatosis, (P < 0.001). In iron overload, two-point Dixon was not evaluable due to confounding T2* effects. FF estimates on six-point Dixon vs MRS-PDFF showed a moderate correlation (0.82) in iron overload vs an excellent correlation (0.97) without iron overload, (P < 0.03). The accuracy of six-point Dixon in grading mild steatosis improved (AUROC: 0.59 to 0.99) when iron overload cases were excluded. The excellent correlation (> 0.9) between the Dixon techniques vs MRS-PDFF did not change in the presence of liver fibrosis (P < 0.01).

Conclusion: Dixon techniques performed satisfactorily for the evaluation of hepatic steatosis but with exceptions.

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来源期刊
World journal of radiology
World journal of radiology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
自引率
8.00%
发文量
35
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