{"title":"两点Dixon和六点Dixon磁共振技术在肝脂肪变性的检测、定量和分级中的应用。","authors":"Mohamed Elfaal, Alanna Supersad, Craig Ferguson, Stephanie Locas, Florin Manolea, Mitchell P Wilson, Medica Sam, Wendy Tu, Gavin Low","doi":"10.4329/wjr.v15.i10.293","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hepatic steatosis is a very common problem worldwide.</p><p><strong>Aim: </strong>To assess the performance of two- and six-point Dixon magnetic resonance (MR) techniques in the detection, quantification and grading of hepatic steatosis.</p><p><strong>Methods: </strong>A single-center retrospective study was performed in 62 patients with suspected parenchymal liver disease. MR sequences included two-point Dixon, six-point Dixon, MR spectroscopy (MRS) and MR elastography. Fat fraction (FF) estimates on the Dixon techniques were compared to the MRS-proton density FF (PDFF). Statistical tests used included Pearson's correlation and receiver operating characteristic.</p><p><strong>Results: </strong>FF estimates on the Dixon techniques showed excellent correlation (≥ 0.95) with MRS-PDFF, and excellent accuracy [area under the receiver operating characteristic (AUROC) ≥ 0.95] in: (1) Detecting steatosis; and (2) Grading severe steatosis, (<i>P</i> < 0.001). In iron overload, two-point Dixon was not evaluable due to confounding T2* effects. FF estimates on six-point Dixon <i>vs</i> MRS-PDFF showed a moderate correlation (0.82) in iron overload <i>vs</i> an excellent correlation (0.97) without iron overload, (<i>P</i> < 0.03). The accuracy of six-point Dixon in grading mild steatosis improved (AUROC: 0.59 to 0.99) when iron overload cases were excluded. The excellent correlation (> 0.9) between the Dixon techniques <i>vs</i> MRS-PDFF did not change in the presence of liver fibrosis (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Dixon techniques performed satisfactorily for the evaluation of hepatic steatosis but with exceptions.</p>","PeriodicalId":23819,"journal":{"name":"World journal of radiology","volume":"15 10","pages":"293-303"},"PeriodicalIF":1.4000,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631370/pdf/","citationCount":"0","resultStr":"{\"title\":\"Two-point Dixon and six-point Dixon magnetic resonance techniques in the detection, quantification and grading of hepatic steatosis.\",\"authors\":\"Mohamed Elfaal, Alanna Supersad, Craig Ferguson, Stephanie Locas, Florin Manolea, Mitchell P Wilson, Medica Sam, Wendy Tu, Gavin Low\",\"doi\":\"10.4329/wjr.v15.i10.293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Hepatic steatosis is a very common problem worldwide.</p><p><strong>Aim: </strong>To assess the performance of two- and six-point Dixon magnetic resonance (MR) techniques in the detection, quantification and grading of hepatic steatosis.</p><p><strong>Methods: </strong>A single-center retrospective study was performed in 62 patients with suspected parenchymal liver disease. MR sequences included two-point Dixon, six-point Dixon, MR spectroscopy (MRS) and MR elastography. Fat fraction (FF) estimates on the Dixon techniques were compared to the MRS-proton density FF (PDFF). Statistical tests used included Pearson's correlation and receiver operating characteristic.</p><p><strong>Results: </strong>FF estimates on the Dixon techniques showed excellent correlation (≥ 0.95) with MRS-PDFF, and excellent accuracy [area under the receiver operating characteristic (AUROC) ≥ 0.95] in: (1) Detecting steatosis; and (2) Grading severe steatosis, (<i>P</i> < 0.001). In iron overload, two-point Dixon was not evaluable due to confounding T2* effects. FF estimates on six-point Dixon <i>vs</i> MRS-PDFF showed a moderate correlation (0.82) in iron overload <i>vs</i> an excellent correlation (0.97) without iron overload, (<i>P</i> < 0.03). The accuracy of six-point Dixon in grading mild steatosis improved (AUROC: 0.59 to 0.99) when iron overload cases were excluded. The excellent correlation (> 0.9) between the Dixon techniques <i>vs</i> MRS-PDFF did not change in the presence of liver fibrosis (<i>P</i> < 0.01).</p><p><strong>Conclusion: </strong>Dixon techniques performed satisfactorily for the evaluation of hepatic steatosis but with exceptions.</p>\",\"PeriodicalId\":23819,\"journal\":{\"name\":\"World journal of radiology\",\"volume\":\"15 10\",\"pages\":\"293-303\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631370/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of radiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4329/wjr.v15.i10.293\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of radiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4329/wjr.v15.i10.293","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Two-point Dixon and six-point Dixon magnetic resonance techniques in the detection, quantification and grading of hepatic steatosis.
Background: Hepatic steatosis is a very common problem worldwide.
Aim: To assess the performance of two- and six-point Dixon magnetic resonance (MR) techniques in the detection, quantification and grading of hepatic steatosis.
Methods: A single-center retrospective study was performed in 62 patients with suspected parenchymal liver disease. MR sequences included two-point Dixon, six-point Dixon, MR spectroscopy (MRS) and MR elastography. Fat fraction (FF) estimates on the Dixon techniques were compared to the MRS-proton density FF (PDFF). Statistical tests used included Pearson's correlation and receiver operating characteristic.
Results: FF estimates on the Dixon techniques showed excellent correlation (≥ 0.95) with MRS-PDFF, and excellent accuracy [area under the receiver operating characteristic (AUROC) ≥ 0.95] in: (1) Detecting steatosis; and (2) Grading severe steatosis, (P < 0.001). In iron overload, two-point Dixon was not evaluable due to confounding T2* effects. FF estimates on six-point Dixon vs MRS-PDFF showed a moderate correlation (0.82) in iron overload vs an excellent correlation (0.97) without iron overload, (P < 0.03). The accuracy of six-point Dixon in grading mild steatosis improved (AUROC: 0.59 to 0.99) when iron overload cases were excluded. The excellent correlation (> 0.9) between the Dixon techniques vs MRS-PDFF did not change in the presence of liver fibrosis (P < 0.01).
Conclusion: Dixon techniques performed satisfactorily for the evaluation of hepatic steatosis but with exceptions.