受新型放射性药物的启发:核医学的高峰时刻。

IF 7 2区 医学 Q1 ONCOLOGY Chinese Journal of Cancer Research Pub Date : 2023-10-30 DOI:10.21147/j.issn.1000-9604.2023.05.05
Yang Liu, Ya-Nan Ren, Yan Cui, Song Liu, Zhi Yang, Hua Zhu, Nan Li
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引用次数: 0

摘要

核医学在肿瘤的诊断和治疗中发挥着不可替代的作用。放射性药物是核医学的重要组成部分。在美国食品和药物管理局(FDA)批准的放射性药物中,靶向前列腺特异性膜抗原(PSMA)和生长抑素受体(SSTR)的放射性示踪剂分别在前列腺癌和神经内分泌肿瘤的诊断和治疗中占有重要地位。近年来,fda批准了一系列针对程序性死亡1 (PD-1)/程序性死亡配体1 (PD-L1)、人表皮生长因子受体2 (HER2)和连接素细胞粘附分子4 (nectin 4)的免疫治疗和靶向治疗药物。如何筛选适合这些治疗的患者并监测治疗效果?特异放射性药物的核医学可以可视化这些靶点在全身病变中的表达水平,并评估治疗效果。除了放射性药物,成像设备也是核医学的关键一步。开发了包括全身正电子发射断层扫描/计算机断层扫描(PET/CT)和正电子发射断层扫描/磁共振成像(PET/MRI)在内的先进设备,为肿瘤的诊断和治疗以及新型放射性药物的开发做出了贡献。在这里,我们总结了核医学中放射性药物的最新进展,它们大大增加了临床医生治疗肿瘤的“武器库”。
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Inspired by novel radiopharmaceuticals: Rush hour of nuclear medicine.

Nuclear medicine plays an irreplaceable role in the diagnosis and treatment of tumors. Radiopharmaceuticals are important components of nuclear medicine. Among the radiopharmaceuticals approved by the Food and Drug Administration (FDA), radio-tracers targeting prostate-specific membrane antigen (PSMA) and somatostatin receptor (SSTR) have held essential positions in the diagnosis and treatment of prostate cancers and neuroendocrine neoplasms, respectively. In recent years, FDA-approved serials of immune-therapy and targeted therapy drugs targeting programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1), human epidermal growth factor receptor 2 (HER2), and nectin cell adhesion molecule 4 (Nectin 4). How to screen patients suitable for these treatments and monitor the therapy? Nuclear medicine with specific radiopharmaceuticals can visualize the expression level of those targets in systemic lesions and evaluate the efficacy of treatment. In addition to radiopharmaceuticals, imaging equipment is also a key step for nuclear medicine. Advanced equipment including total-body positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI) has been developed, which contribute to the diagnosis and treatment of tumors, as well as the development of new radiopharmaceuticals. Here, we conclude most recently advances of radiopharmaceuticals in nuclear medicine, and they substantially increase the "arsenal" of clinicians for tumor therapy.

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来源期刊
自引率
9.80%
发文量
1726
审稿时长
4.5 months
期刊介绍: Chinese Journal of Cancer Research (CJCR; Print ISSN: 1000-9604; Online ISSN:1993-0631) is published by AME Publishing Company in association with Chinese Anti-Cancer Association.It was launched in March 1995 as a quarterly publication and is now published bi-monthly since February 2013. CJCR is published bi-monthly in English, and is an international journal devoted to the life sciences and medical sciences. It publishes peer-reviewed original articles of basic investigations and clinical observations, reviews and brief communications providing a forum for the recent experimental and clinical advances in cancer research. This journal is indexed in Science Citation Index Expanded (SCIE), PubMed/PubMed Central (PMC), Scopus, SciSearch, Chemistry Abstracts (CA), the Excerpta Medica/EMBASE, Chinainfo, CNKI, CSCI, etc.
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