食管癌放疗和免疫联合治疗的最新数据更新:关注疗效、安全性和生物标志物。

IF 7 2区 医学 Q1 ONCOLOGY Chinese Journal of Cancer Research Pub Date : 2023-10-30 DOI:10.21147/j.issn.1000-9604.2023.05.06
Shuping Cheng, Butuo Li, Jinming Yu, Linlin Wang
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引用次数: 0

摘要

食管癌通常预后较差。鉴于肿瘤免疫治疗的重大突破,越来越多的临床研究表明,放疗与免疫检查点抑制剂(ici)联合治疗食管癌可能具有协同效应和良好的预后。从2021年到现在,食管癌免疫放射治疗(iRT)的临床研究激增。然而,目前还缺乏对综合治疗的疗效和毒性的总结,以指导食管癌的临床治疗。在这篇综述中,我们整合了最新的数据来分析和评估iRT治疗食管癌的有效性和安全性。此外,我们还讨论了更好的预测性生物标志物,针对特定人群的治疗选择以及其他挑战,以确定未来研究设计的方向。
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Update of latest data for combined therapy for esophageal cancer using radiotherapy and immunotherapy: A focus on efficacy, safety, and biomarkers.

Esophageal cancer usually has a poor prognosis. Given the significant breakthrough with tumor immunotherapy, an increasing number of clinical studies have demonstrated that the combination of radiotherapy and immune checkpoint inhibitors (ICIs) may have a synergistic effect and good outcome in esophageal cancer. Clinical studies of immunoradiotherapy (iRT) for esophageal cancer have proliferated enormously from 2021 to the present. However, a summary of the efficacy and toxicity of combined therapy to guide esophageal cancer treatment in clinical practice is lacking. For this review, we integrate the latest data to analyze and assess the efficacy and safety of iRT for esophageal cancer. In addition, we discuss better predictive biomarkers, therapeutic options for specific populations, and other challenges to identify directions for future research design.

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来源期刊
自引率
9.80%
发文量
1726
审稿时长
4.5 months
期刊介绍: Chinese Journal of Cancer Research (CJCR; Print ISSN: 1000-9604; Online ISSN:1993-0631) is published by AME Publishing Company in association with Chinese Anti-Cancer Association.It was launched in March 1995 as a quarterly publication and is now published bi-monthly since February 2013. CJCR is published bi-monthly in English, and is an international journal devoted to the life sciences and medical sciences. It publishes peer-reviewed original articles of basic investigations and clinical observations, reviews and brief communications providing a forum for the recent experimental and clinical advances in cancer research. This journal is indexed in Science Citation Index Expanded (SCIE), PubMed/PubMed Central (PMC), Scopus, SciSearch, Chemistry Abstracts (CA), the Excerpta Medica/EMBASE, Chinainfo, CNKI, CSCI, etc.
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