钠稳态和信号传导:星形胶质细胞功能的核心和枢纽

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2023-11-04 DOI:10.1016/j.ceca.2023.102817
Christine R. Rose , Alexej Verkhratsky
{"title":"钠稳态和信号传导:星形胶质细胞功能的核心和枢纽","authors":"Christine R. Rose ,&nbsp;Alexej Verkhratsky","doi":"10.1016/j.ceca.2023.102817","DOIUrl":null,"url":null,"abstract":"<div><p><span>Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na</span><sup>+</sup> ions in astrocytes. These changes constitute the substrate for Na<sup>+</sup> signalling and are fundamental for astrocytic excitability. Astrocytic Na<sup>+</sup> signals are generated by Na<sup>+</sup><span><span> influx through neurotransmitter transporters, with primary contribution of </span>glutamate transporters, and through cationic channels; whereas recovery from Na</span><sup>+</sup> transients is mediated mainly by the plasmalemmal Na<sup>+</sup>/K<sup>+</sup><span> ATPase. Astrocytic Na</span><sup>+</sup> signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.</p></div>","PeriodicalId":9678,"journal":{"name":"Cell calcium","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sodium homeostasis and signalling: The core and the hub of astrocyte function\",\"authors\":\"Christine R. Rose ,&nbsp;Alexej Verkhratsky\",\"doi\":\"10.1016/j.ceca.2023.102817\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na</span><sup>+</sup> ions in astrocytes. These changes constitute the substrate for Na<sup>+</sup> signalling and are fundamental for astrocytic excitability. Astrocytic Na<sup>+</sup> signals are generated by Na<sup>+</sup><span><span> influx through neurotransmitter transporters, with primary contribution of </span>glutamate transporters, and through cationic channels; whereas recovery from Na</span><sup>+</sup> transients is mediated mainly by the plasmalemmal Na<sup>+</sup>/K<sup>+</sup><span> ATPase. Astrocytic Na</span><sup>+</sup> signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.</p></div>\",\"PeriodicalId\":9678,\"journal\":{\"name\":\"Cell calcium\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2023-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell calcium\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0143416023001288\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell calcium","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0143416023001288","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

神经元活动和神经化学刺激引发星形胶质细胞胞质Na+离子浓度的时空变化。这些变化构成Na+信号传导的底物,是星形细胞兴奋性的基础。星形胶质细胞Na+信号是由Na+通过神经递质(主要是谷氨酸转运体)内流并通过阳离子通道产生的;而Na+瞬态的恢复主要是由细胞质Na+/K+ atp酶介导的。星形胶质细胞Na+信号调节对星形胶质细胞稳态功能至关重要的质浆转运蛋白的活性,从而在神经元活动和星形胶质细胞支持之间提供实时协调。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Sodium homeostasis and signalling: The core and the hub of astrocyte function

Neuronal activity and neurochemical stimulation trigger spatio-temporal changes in the cytoplasmic concentration of Na+ ions in astrocytes. These changes constitute the substrate for Na+ signalling and are fundamental for astrocytic excitability. Astrocytic Na+ signals are generated by Na+ influx through neurotransmitter transporters, with primary contribution of glutamate transporters, and through cationic channels; whereas recovery from Na+ transients is mediated mainly by the plasmalemmal Na+/K+ ATPase. Astrocytic Na+ signals regulate the activity of plasmalemmal transporters critical for homeostatic function of astrocytes, thus providing real-time coordination between neuronal activity and astrocytic support.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
期刊最新文献
Calcium signals as regulators of ferroptosis in cancer GPCR signalling: Yet another variant route in a highly complex road map Does a transmembrane sodium gradient control membrane potential in mammalian mitochondria? Calcium and chloride out of sync: The role of signaling in Sjögren's salivary gland issues Corrigendum to “Loss-of-function W4645R mutation in the RyR2-caffeine binding site: implications for synchrony and arrhythmogenesis” [Cell Calcium 123 (2024) 102925]
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1