N-acetylation of aromatic amines by one-pot route

aims: To achieve acylation of aryl amine via one-pot route. background: Amides are one of the most common and important structural motifs. Several different strategies have been employed to produce acetamide. However, some of these methods require bases, prolonged reaction times, metal catalysis, or toxic reagents. To overcome these limitations, a new method for the synthesis of N-acetanilide is needed. objective: We have to develope an economical, efficient, and metal-free strategy for synthesizing N-acetanilide by reacting aniline with CH3CN and DMSO. method: The amidation was performed in presence of H2O and K2S2O8 in a mixed solvent (CH3CN:DMSO). result: A series of amide compounds using K2S2O8 as the oxidant and amines as substrates in acetonitrile and water without any transition metals is reported. conclusion: The method uses simple, easily available materials in a straightforward protocol that allows the ease of isolating the products other: No other contents.