Intralesional injection of mumps, measles, and rubella vaccine, bleomycin, and vitamin D3 in warts treatment

Objectives To compare the therapeutic efficacy of intralesional mumps, measles, and rubella (MMR) vaccination, vitamin D3 (VitD3), and bleomycin injection in patients with warts. Background With good outcomes, common warts have been treated with immunotherapy using intralesional antigens or vaccinations. It might result in resolution without any outward signs of deterioration or scarring and boost the host’s defenses against the agent that caused the problem. Methods This study involved 84 wart patients in Benha University Hospitals, Egypt. All study participants gave their consent after being informed. MMR, bleomycin, and VitD3 were injected intralesionally to treat warts, whereas normal saline was injected intralesionally in control patients. Patients were followed every session for the size of the mother wart to record the effect of therapy. Results Comparing the response of mother wart at the last follow-up after MMR, vitD3, or bleomycin injection versus the control group revealed a significantly better response in each modality compared to control groups (P