与添加氧化锌相比,饲粮中添加吡咯喹啉醌可促进仔猪生长,缓解断奶应激,调节仔猪代谢

IF 6.3 Animal Nutrition Pub Date : 2023-10-04 DOI:10.1016/j.aninu.2023.06.015
Chenyu Shi , Zirou Yu , Zijie Wang , Ran Ning , Caiyun Huang , Youjun Gao , Fenglai Wang
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引用次数: 0

摘要

断奶仔猪由于心理压力和环境压力,往往会出现生长障碍。本试验旨在比较添加吡咯喹啉醌(PQQ)和氧化锌(ZnO)对断奶仔猪生长性能、腹泻指标、营养物质消化率、抗氧化能力、神经递质水平和代谢的影响。28 d断奶仔猪(n = 108)分别饲喂基础饲粮(CTRL组)、基础饲粮中添加3.0 mg/kg PQQ (PQQ组)和基础饲粮中添加1600 mg/kg氧化锌(ZnO组)3种不同的饲粮。前14 d,饲粮中添加PQQ和ZnO显著降低了仔猪料重比和腹泻率(P < 0.01)。与对照组相比,PQQ组断奶仔猪15 ~ 28 d的平均日增重显著提高(P = 0.03)。与对照组相比,添加PQQ和氧化锌的饲粮提高了饲粮中营养物质的表观全道消化率(ATTD) (P≤0.05)。在整个试验期内,PQQ组和氧化锌组猪血浆丙二醛浓度均低于对照组(P < 0.05)。第28 d时,PQQ组和氧化锌组断奶仔猪血浆血管活性肠肽(VIP)和降钙素基因相关肽(CGRP)浓度低于对照组(P < 0.05)。PQQ组和氧化锌组在生长性能、营养ATTD、抗氧化能力和神经递质水平方面无显著差异。与对照组相比,PQQ组3-甲氧基-4-羟基扁桃酸升高(P < 0.05)。代谢组学分析显示,PQQ组芥子酰胺、刺芒柄花素和3-甲基- l-组氨酸水平上调(P < 0.05)。与对照组相比,PQQ组芦荟素和己二酸二丁酯表达下调(P < 0.05)。综上所述,与氧化锌相似,PQQ提高了断奶仔猪的生长性能、营养物质消化率、抗氧化能力、神经调节和代谢。因此,与氧化锌一样,PQQ可以有效地应用于断奶仔猪。
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Dietary supplementation with pyrroloquinoline quinone promotes growth, relieves weaning stress, and regulates metabolism of piglets compared with adding zinc oxide

Hindered growth often occurs because of psychological and environmental stress during the weaning period of piglets. This study aimed to compare the effects of growth performance, diarrhea indices, digestibility of nutrients, antioxidant capacity, neurotransmitters levels and metabolism of weaned pigs fed diets supplemented with pyrroloquinoline quinone (PQQ) and zinc oxide (ZnO). Pigs weaned at d 28 (n = 108) were fed with three different diets including: the basal diet (CTRL group), the basal diet supplemented with 3.0 mg/kg PQQ (PQQ group) and the basal diet containing 1,600 mg/kg ZnO (ZNO group). During the first 14 d, weaned pigs fed the diet supplemented with PQQ and ZnO decreased feed to gain ratio and diarrhea rate (P < 0.01). Compared with the CTRL group, average daily gain was increased in weaned pigs in the PQQ group from d 15 to 28 (P = 0.03). Compared with the CTRL group, pigs fed PQQ and ZnO supplemented diets showed improved apparent total tract digestibility (ATTD) of nutrients (P ≤ 0.05). During the overall experimental period, the concentration of malondialdehyde was decreased in plasma of pigs in the PQQ and ZNO groups compared with the CTRL group (P < 0.05). At d 28, the concentration of vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide (CGRP) was lower in plasma of weaned pigs in the PQQ and ZNO groups compared with the CTRL group (P < 0.05). There was no difference between the PQQ and ZNO group in growth performance, ATTD of nutrition, antioxidant capacity and neurotransmitters levels. PQQ increased 3-methoxy-4-hydroxymandelate (P < 0.05) compared with the CTRL group. According to metabolomic analysis, erucamide, formononetin and 3-methyl-L-histidine were up-regulated in the PQQ group (P < 0.05). Compared with the CTRL group, aloesin and dibutyl adipate were down-regulated in the PQQ group (P < 0.05). In conclusion, similar to ZnO, PQQ improves growth performance, digestibility of nutrients, antioxidant capacity, neuromodulation and metabolism of weaned pigs. Thus, like ZnO, PQQ can be effectively applied in weaned pigs.

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来源期刊
Animal Nutrition
Animal Nutrition Animal Science and Zoology
CiteScore
9.70
自引率
0.00%
发文量
542
审稿时长
65 days
期刊介绍: Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to primarily to the nutrition of farm animals and aquatic species. More applied aspects of animal nutrition, such as the evaluation of novel ingredients, feed additives and feed safety will also be considered but it is expected that such studies will have a strong nutritional focus. Animal Nutrition is indexed in SCIE, PubMed Central, Scopus, DOAJ, etc.
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