界面流变学原理及其在药物制剂(预)配方开发中的应用

Q4 Pharmacology, Toxicology and Pharmaceutics Arhiv za Farmaciju Pub Date : 2023-01-01 DOI:10.5937/arhfarm73-46316
Veljko Krstonošić, Nebojša Pavlović, Dejan Ćirin
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引用次数: 0

摘要

流变学是研究材料运动和变形的科学,而界面流变学是流变学的一个分支,主要研究流体界面的力学性质,如液-液和液-气界面。流体界面的行为与块状材料的行为有很大的不同,块状材料的标准流变测量不能充分描述其性质。界面流变学是研究液体界面粘弹性和界面张力的一种专门方法,为分子间相互作用和表面力提供了有价值的见解。这些知识对于开发具有定制属性和功能的高级配方和系统尤其重要。界面流变学是一个快速发展的研究领域,在科学和工业上有着广泛的应用。它在药物配方的开发和优化以及创新药物递送载体的设计中发挥着关键作用,具有更好的稳定性,增强的药物释放谱和靶向递送能力。本文综述了界面流变学的基本原理、测量技术及其在工业中的应用。通过探索该领域的最新进展和新兴趋势,我们的目标是强调界面流变学在优化配方,提高产品性能和推动创新方面的重要性,特别是在制药科学方面。
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Principles and applications of interfacial rheology in (pre)formulation development of pharmaceutical preparations
Rheology is a science that deals with the movement and deformation of materials, while interfacial rheology is a branch of rheology that focuses on the study of the mechanical properties of fluid interfaces, such as liquid-liquid and liquid-gas interfaces. The behavior of fluid interfaces differs significantly from that of bulk materials, and standard rheological measurements of bulk materials cannot adequately describe their properties. Interfacial rheology is a specialized approach to the study of viscoelasticity and interfacial tension at liquid interfaces and provides valuable insight into intermolecular interactions and surface forces. This knowledge is particularly important for the development of advanced formulations and systems with tailored properties and functionalities. Interfacial rheology is a rapidly growing research field with diverse applications in science and industry. It plays a pivotal role in the development and optimization of pharmaceutical formulations and design of innovative drug delivery carriers with improved stability, enhanced drug release profiles, and targeted delivery capabilities. This review article aims to provide a comprehensive overview of interfacial rheology, its principles, measurement techniques, and applications in various industries. By exploring recent advancements and emerging trends in the field, we aim to highlight the significance of interfacial rheology in optimizing formulations, enhancing product performance, and driving innovations, particularly in pharmaceutical science.
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来源期刊
Arhiv za Farmaciju
Arhiv za Farmaciju Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
自引率
0.00%
发文量
19
审稿时长
12 weeks
期刊最新文献
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