口服弯曲乳杆菌LB-P9可促进小鼠毛发再生

IF 4.2 3区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Food Science of Animal Resources Pub Date : 2023-11-14 DOI:10.5851/kosfa.2023.e74
Mikyung Song, Jaeseok Shim, Kyoungsub Song
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引用次数: 0

摘要

本研究旨在探讨弯曲乳杆菌LB-P9对头发再生的影响。LB-P9条件培养基(CM)对毛囊真皮乳头细胞(hFDPCs)和毛发生发基质细胞(hGMCs)的增殖均有促进作用。此外,与LB-P9共培养的hgmc中,毛发生长因子如血管内皮生长因子(VEGF)和成纤维细胞生长因子7 (FGF-7)的表达水平显著升高。时间同步脱毛后,小鼠口服LB-P9集落形成单位(CFU) 4×107(低剂量)或LB-P9集落形成单位4×108 (CFU)(高剂量),每天1次,持续4周。与载体(磷酸盐缓冲盐水,PBS)组相比,lb - p9处理组表现出加速的头发再生速度和增加的头发厚度,并呈剂量依赖性。与载体组相比,lb - p9处理组的毛囊数量和皮肤组织的真皮厚度都增加了,这支持了这一观察结果。这些结果可能是由于给药LB-P9的小鼠皮肤组织中β-catenin水平和毛囊干细胞(CD34+CD49f+细胞)数量的增加。此外,与载体处理组相比,lb - p9处理组血清中头发生长因子(如VEGF、胰岛素样生长因子-1 (IGF-1))和超氧化物歧化酶(SOD)的水平也有所增加。综上所述,这些结果可能表明,口服LB-P9通过刺激毛发生长因子的产生,促进真皮乳头增殖,从而促进毛发再生。
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Oral administration of Lactilactobacillus curvatus LB-P9 promotes hair regeneration in mice
This study was designed to examine the effect of Lactilactobacillus curvatus LB-P9 on hair regeneration. The treatment of LB-P9 conditioned medium (CM) increased the proliferation of both hair follicle dermal papilla cells (hFDPCs) and hair germinal matrix cells (hGMCs). Moreover, the expression levels of hair growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor 7 (FGF-7) were significantly elevated in hGMCs co-cultured with LB-P9. After time-synchronized depilation, mice were orally administered with either 4×107 colony forming unit (CFU) of LB-P9 (low dose) or 4×108 CFU of LB-P9 (high dose), once daily for 4 weeks. Compared with the vehicle (phosphate-buffered saline, PBS)-administrated group, the LB-P9-treated groups exhibited accelerated hair regrowth rate and enhanced hair thickness in a dose-dependent manner. Supporting this observation, both hair follicle numbers and the dermal thickness in skin tissues of the LB-P9-treated groups were increased, compared to those of the vehicle-treated group. These results might be explained by the increased level of β-catenin and number of hair follicle stem cells (hFSCs) (CD34+CD49f+ cells) in the skin tissues of mice administered with LB-P9, compared to the vehicle-treated mice. Also, increased serum levels of hair growth factors such as VEGF and insulin-like growth factor-1 (IGF-1), and superoxide dismutase (SOD) were found in the LB-P9-treated groups, compared to those of the vehicle-treated group. Taken together, these results might demonstrate that the oral administration of LB-P9 promotes hair regeneration by the enhancement of dermal papilla proliferation through the stimulation of hair growth factor production.
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来源期刊
Food Science of Animal Resources
Food Science of Animal Resources Agricultural and Biological Sciences-Animal Science and Zoology
CiteScore
6.70
自引率
6.70%
发文量
75
期刊介绍: Food Science of Animal Resources (Food Sci. Anim. Resour.) is an international, peer-reviewed journal publishing original research and review articles on scientific and technological aspects of chemistry, biotechnology, processing, engineering, and microbiology of meat, egg, dairy, and edible insect/worm products.
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