预测关键人群艾滋病病毒感染率缺失的多变量空间模型

Zhou Lan, Le Bao
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摘要

终结艾滋病毒/艾滋病流行病是今后十年的可持续发展目标之一。为了克服护理需要与有限资源之间的不平衡所造成的问题,我们应增进对当地艾滋病毒流行情况的了解,特别是对艾滋病毒感染高风险的关键人群的了解。然而,关键人群的艾滋病毒流行率很难估计,因为他们的艾滋病毒监测数据非常少。本文建立了一个多变量空间模型,用于预测关键人群中未知的艾滋病毒流行率。提出的多变量条件自回归模型可以有效地从邻近位置和相关人群中提取信息。正如实际数据分析所表明的那样,它提供了比独立拟合每个关键人群的亚流行病更准确的预测。此外,我们研究了不同的监测数据对预测的贡献,并为流行病数据收集提供了实用的建议。
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Multivariate spatial modelling for predicting missing HIV prevalence rates among key populations
Abstract Ending the HIV/AIDS pandemic is among the sustainable development goals for the next decade. To overcome the problem caused by the imbalances between the need for care and the limited resources, we shall improve our understanding of the local HIV epidemics, especially for key populations at high risk of HIV infection. However, HIV prevalence rates for key populations have been difficult to estimate because their HIV surveillance data are very scarce. This paper develops a multivariate spatial model for predicting unknown HIV prevalence rates among key populations. The proposed multivariate conditional auto-regressive model efficiently pools information from neighbouring locations and correlated populations. As the real data analysis illustrates, it provides more accurate predictions than independently fitting the sub-epidemic for each key population. Furthermore, we investigate how different pieces of surveillance data contribute to the prediction and offer practical suggestions for epidemic data collection.
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