{"title":"生姜和南瓜籽联合提取物对环磷酰胺诱导的大鼠肝毒性的保护作用","authors":"Hamed Haddad Kashani, Maryam Taheri, Zeinab Qotbi, Abolfazl Zahedi, Fatemeh Izadpanah, Hossein Nikzad","doi":"10.1007/s13596-023-00721-2","DOIUrl":null,"url":null,"abstract":"<div><p>Cyclophosphamide is an alkylating agent that is widely used in cancer therapy. An important complication of this drug is hepatotoxicity. The hepatic prophylactic effects of ginger and pumpkin seeds were observed due to antioxidant effect. In the current study, the effects of ginger, pumpkin seed extracts, and their combination on cyclophosphamide-induced hepatotoxicity in rats were investigated. In this intervention study, a total of 70 male rats were randomly divided into 10 groups. The blood was taken after 2 weeks of treatment. Liver enzyme levels including ALT, AST and MDA were measured. Sections of the livers of all groups were provided and then histologically evaluated. The data obtained were analyzed using SPSS software version 16. A significant increase in liver enzymes was observed in rats treated with cyclophosphamide compared to other groups. Liver enzyme levels were decreased in rats treated with ginger, pumpkin seed and combined extracts (<i>P</i> < 0.05). Histological examination of liver samples treated with ginger, pumpkin seeds and combined extracts showed a significant reduction in liver damage compared to the cyclophosphamide-treated group (<i>P</i> < 0.05). Ginger, pumpkin seeds and combined extracts could improve biochemical parameters such as AST and ALT and pathological damage in the liver of cyclophosphamide-treated rats.</p></div>","PeriodicalId":7613,"journal":{"name":"Advances in Traditional Medicine","volume":"24 2","pages":"583 - 591"},"PeriodicalIF":1.8000,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protective effect of combined ginger and pumpkin seed extracts on cyclophosphamide-induced hepatotoxicity in rats\",\"authors\":\"Hamed Haddad Kashani, Maryam Taheri, Zeinab Qotbi, Abolfazl Zahedi, Fatemeh Izadpanah, Hossein Nikzad\",\"doi\":\"10.1007/s13596-023-00721-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cyclophosphamide is an alkylating agent that is widely used in cancer therapy. An important complication of this drug is hepatotoxicity. The hepatic prophylactic effects of ginger and pumpkin seeds were observed due to antioxidant effect. In the current study, the effects of ginger, pumpkin seed extracts, and their combination on cyclophosphamide-induced hepatotoxicity in rats were investigated. In this intervention study, a total of 70 male rats were randomly divided into 10 groups. The blood was taken after 2 weeks of treatment. Liver enzyme levels including ALT, AST and MDA were measured. Sections of the livers of all groups were provided and then histologically evaluated. The data obtained were analyzed using SPSS software version 16. A significant increase in liver enzymes was observed in rats treated with cyclophosphamide compared to other groups. Liver enzyme levels were decreased in rats treated with ginger, pumpkin seed and combined extracts (<i>P</i> < 0.05). Histological examination of liver samples treated with ginger, pumpkin seeds and combined extracts showed a significant reduction in liver damage compared to the cyclophosphamide-treated group (<i>P</i> < 0.05). Ginger, pumpkin seeds and combined extracts could improve biochemical parameters such as AST and ALT and pathological damage in the liver of cyclophosphamide-treated rats.</p></div>\",\"PeriodicalId\":7613,\"journal\":{\"name\":\"Advances in Traditional Medicine\",\"volume\":\"24 2\",\"pages\":\"583 - 591\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2023-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Traditional Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13596-023-00721-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Traditional Medicine","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s13596-023-00721-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Protective effect of combined ginger and pumpkin seed extracts on cyclophosphamide-induced hepatotoxicity in rats
Cyclophosphamide is an alkylating agent that is widely used in cancer therapy. An important complication of this drug is hepatotoxicity. The hepatic prophylactic effects of ginger and pumpkin seeds were observed due to antioxidant effect. In the current study, the effects of ginger, pumpkin seed extracts, and their combination on cyclophosphamide-induced hepatotoxicity in rats were investigated. In this intervention study, a total of 70 male rats were randomly divided into 10 groups. The blood was taken after 2 weeks of treatment. Liver enzyme levels including ALT, AST and MDA were measured. Sections of the livers of all groups were provided and then histologically evaluated. The data obtained were analyzed using SPSS software version 16. A significant increase in liver enzymes was observed in rats treated with cyclophosphamide compared to other groups. Liver enzyme levels were decreased in rats treated with ginger, pumpkin seed and combined extracts (P < 0.05). Histological examination of liver samples treated with ginger, pumpkin seeds and combined extracts showed a significant reduction in liver damage compared to the cyclophosphamide-treated group (P < 0.05). Ginger, pumpkin seeds and combined extracts could improve biochemical parameters such as AST and ALT and pathological damage in the liver of cyclophosphamide-treated rats.
期刊介绍：
Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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