埃塞俄比亚西北部菲利格·希沃特综合专科医院内科和妇科病房万古霉素应用评价

IF 2.1 4区 医学 Q3 PHARMACOLOGY & PHARMACY Journal of Clinical Pharmacy and Therapeutics Pub Date : 2023-09-19 DOI:10.1155/2023/2335694
Baye Yrga Adugna, Zewdu Yilma Dlie, Biset Asrade Mekonnen, Abebe Tarekegn Kassaw
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引用次数: 0

摘要

背景。药物使用评估是一种侧重于评估和优化药物使用实践以实现最佳患者结果的方法。本研究的目的是评估万古霉素使用模式的适宜性及其在住院患者中的实际应用。方法。在2022年5月1日至2022年7月30日期间,对265名住院患者进行了基于机构的描述性回顾性横断面研究设计。研究参与者采用简单的随机抽样方法进行选择。结果。265名研究参与者中,60.4%为男性,接受万古霉素治疗的占86.8%;然而,13.2%的人接受了预防治疗。此外,用于治疗脑膜炎和肺炎的万古霉素分别占41.9%和27.5%。只有17.4%的患者进行了培养,82.6%的患者使用万古霉素进行经验性治疗。万古霉素在800 ~ 1000mg剂量范围内用药最多(66.8%)。结果表明,分别有57.36%和39.25%是由于不正确的剂量和持续时间。只有17.4%的患者进行了敏感性测试。结论。万古霉素不适宜是常见的适应症,剂量,频率和治疗时间根据指南。万古霉素主要作为经验性治疗,即使进行了少量的敏感试验。鉴于万古霉素作为经验性药物的广泛使用,应密切监测其使用情况。因此,建议采用通常的敏感试验来识别那些中间和耐药结果,并预测治疗结果。
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Evaluation of Vancomycin Utilization in the Medical and Gynecology Wards of Felege Hiwot Comprehensive Specialized Hospital, Northwest Ethiopia
Background. Drug use evaluation is an approach that focuses on evaluating and optimizing drug use practices to achieve the best possible patient outcomes. The purpose of this study was to assess the appropriateness of vancomycin usage patterns and their practical application in hospitalized patients. Methods. An institutional-based descriptive retrospective cross-sectional study design was carried out among 265 hospitalized patients from May 1, 2022, to July 30, 2022. The study participants were selected using a simple random sampling method. Result. Among the 265 study participants, 60.4% were male respondents, while 86.8% of vancomycin was administered for treatment; however, 13.2% was administered for prophylaxis. In addition, 41.9% and 27.5% of vancomycin were ordered for treatment of meningitis and pneumonia, respectively. The culture was performed for only 17.4% of patients, and 82.6% of vancomycin was used for empiric therapy. Most (66.8%) of vancomycin was given in the dose range of 800–1000 mg. The finding indicates that 57.36% and 39.25% were due to incorrect doses and durations, respectively. Only 17.4% of patients had sensitivity tests. Conclusions. Vancomycin inappropriateness was common with the indication, dose, frequency, and duration of therapy according to the guidelines. Vancomycin was mostly indicated as empiric therapy, even though the sensitive test was performed in a small amount. Given the widespread use of vancomycin as an empiric drug, its utilization should be monitored closely. Therefore, the usual sensitive test is recommended to identify those intermediate and resistant results and to predict the outcomes of the treatment.
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来源期刊
CiteScore
4.10
自引率
5.00%
发文量
226
审稿时长
6 months
期刊介绍: The Journal of Clinical Pharmacy and Therapeutics provides a forum for clinicians, pharmacists and pharmacologists to explore and report on issues of common interest. Reports and commentaries on current issues in medical and pharmaceutical practice are encouraged. Papers on evidence-based clinical practice and multidisciplinary collaborative work are particularly welcome. Regular sections in the journal include: editorials, commentaries, reviews (including systematic overviews and meta-analyses), original research and reports, and book reviews. Its scope embraces all aspects of clinical drug development and therapeutics, including: Rational therapeutics Evidence-based practice Safety, cost-effectiveness and clinical efficacy of drugs Drug interactions Clinical impact of drug formulations Pharmacogenetics Personalised, stratified and translational medicine Clinical pharmacokinetics.
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