电导率,一种再生工程方法来逆转肩袖肌退变

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Regenerative Biomaterials Pub Date : 2023-11-11 DOI:10.1093/rb/rbad099
Nikoo Saveh Shemshaki, Mohammed A Barajaa, Takayoshi Otsuka, Elnaz S Mirdamadi, Lakshmi S Nair, Cato T Laurencin
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引用次数: 0

摘要

摘要肌腱套撕裂成功修复后,肌肉退变是导致撕裂率高的主要因素之一。目前的外科手术未能治疗慢性大面积肩袖撕裂患者。因此,人们正在研究再生工程方法来解决这些挑战。近年来的研究表明,电活性材料在电兴奋性组织(如骨骼肌)的再生方面有很好的效果。在这里,我们回顾了肩袖肌退变的最重要的生物学机制。此外,综述了近年来关于电活性材料用于肌肉再生的研究,包括肩袖肌。最后,我们将讨论电活性材料在肩袖撕裂增强术中的应用方向。
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Electroconductivity, a Regenerative Engineering Approach to Reverse Rotator Cuff Muscle Degeneration
Abstract Muscle degeneration is one the main factors that lead to the high rate of retear after a successful repair of rotator cuff tears. The current surgical practices have failed to treat patients with chronic massive rotator cuff tears. Therefore, regenerative engineering approaches are being studied to address the challenges. Recent studies showed the promising outcomes of electroactive materials on the regeneration of electrically excitable tissues such as skeletal muscle. Here, we review the most important biological mechanism of rotator cuff muscle degeneration. Further, the review covers the recent studies on electroactive materials for muscle regeneration including rotator cuff muscle. Finally, we will discuss the future direction toward the application of electroactive materials for the augmentation of rotator cuff tears.
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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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