冻干β-磷酸三钙/钛酸钡/胶原复合骨组织工程支架的制备与表征

IF 2.7 Q1 MATERIALS SCIENCE, CERAMICS Ceramics-Switzerland Pub Date : 2023-11-11 DOI:10.3390/ceramics6040132
Dwi Fortuna Anjusa Putra, Bramantyo Bayu Aji, Henni Setia Ningsih, Ting-Wei Wu, Akihiro Nakanishi, Toshihiro Moriga, Shao-Ju Shih
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引用次数: 0

摘要

冻干法产生了具有许多优点的复合介孔结构支架。然而,像β-磷酸三钙(β-TCP)这样的日常材料几十年来一直被用作矫形植入物来治疗犬类部落骨缺损,例如,用于移植形状均匀的材料来形成我们牙齿的植入物。然而,由于其高生物可降解性,这种材料仍不完全有望成为最好的植入物。除此之外,在骨骼上使用压电效应可以提高细胞生长的效率,加快患者的愈合时间。基于这一现象,对钛酸钡等压电材料(BaTiO3/BT)的支架复合材料进行了测试。根据BT/β-TCP的比值,BT与β-TCP复合支架的孔隙度范围为30.25±11.28 ~ 15.25±11.28 μm。BT/β-TCP比值影响样品的孔隙类型,从而影响样品的力学性能。在我们的研究结果中,45.0 wt% BT/45.0 wt% β-TCP/10.0 wt%胶原的支架达到了最大应力0.5 MPa的显著值,孔径为25.32±8.05 μm。最后,我们进行了活力测试来观察样品的压电效应,通过在样品上生长MC3T3-E1细胞来测试压电效应确实增加了骨愈合时间。
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Preparation and Characterization of Freeze-Dried β-Tricalcium Phosphate/Barium Titanate/Collagen Composite Scaffolds for Bone Tissue Engineering in Orthopedic Applications
The freeze-drying method creates a scaffold with a composite mesoporous structure with many advantages. However, everyday materials such as β-tricalcium phosphate (β-TCP) have been used as an orthopedic implant for canine tribal bone defects for decades, for instance, for grafting material of even shapes to form an implant for our teeth. However, this material is still not entirely expected to be the best implant due to its high biodegradability. Besides that, using the piezoelectric effect on the bone can lead to more efficiency in cell growth and a faster healing time for patients. Based on this phenomenon, a scaffold composite with a piezoelectric material such as barium titanate (BaTiO3/BT) has been tested. Based on the BT/β-TCP ratio, the scaffold composite of BT and β-TCP produces a porous structure with porosity ranging from 30.25 ± 11.28 to 15.25 ± 11.28 μm. The BT/β-TCP ratio influences the samples’ pore type, which affects each sample’s mechanical properties. In our result, the scaffold of 45.0 wt% BT/45.0 wt% β-TCP/10.0 wt% collagen has achieved a significant value of 0.5 MPa for maximum stress with a sufficient pore size of 25.32 ± 8.05 μm. Finally, we performed a viability test to see the sample’s piezoelectric effect, which showed that the piezoelectric effect does increase bone healing time when tested by growing MC3T3-E1 cells on the samples.
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来源期刊
CiteScore
3.00
自引率
7.10%
发文量
66
审稿时长
10 weeks
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