β-2微球蛋白和胱抑素C作为小儿HIV感染局灶节段性肾小球硬化的尿液生物标志物的作用

K Persad, L Nandlal, R Bhimma, T Naicker
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引用次数: 0

摘要

背景。非洲是艾滋病感染率最高的地区,艾滋病相关肾病(HIV -associated nephropathy, HIVAN)是儿童中最常见的肾脏疾病之一。儿童HIVAN通常表现为肾病综合征的一种形式,在组织病理学上以局灶节段性肾小球硬化(FSGS)为主,常导致慢性肾衰竭。本研究测定了hiv和原发性fsgs患儿尿中β-2-微球蛋白(β2M)和胱抑素C蛋白的浓度。研究小组包括34名儿童;14例HIVAN, 20例原发性FSGS。对照组为20名hiv阳性和20名hiv阴性无肾脏疾病的儿童。这74名儿童的尿液样本保存在-80°C。采用Bio-Plextechnology检测尿胱抑素C和β 2m蛋白浓度。与hiv阴性组相比,hiv组尿β2M水平显著升高(p=0.0240)。各研究组尿β2M浓度没有其他统计学上的显著差异。与hiv阴性(p=0.0041)和hiv阳性对照(p=0.0256)相比,原发性FSGS患儿尿胱抑素C水平显著升高。与HIVAN组相比,原发性FSGS患者尿胱抑素C水平显著升高(p=0.0150)。与hiv阴性和hiv阳性对照组相比,hiv组尿胱抑素C水平无显著差异。尿胱抑素C在预测由hiv引起的原发性FSGS方面具有良好的预后价值。
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The role of β-2-microglobulin and cystatin C as urinary biomarkers of focal segmental glomerulosclerosis in the setting of paediatric HIV infection
Background. Africa has the highest rate of HIV infection, and HIV-associated nephropathy (HIVAN) is one of the most frequent kidneydiseases observed in children. HIVAN in children usually presents as a form of nephrotic syndrome, predominantly focal segmentalglomerulosclerosis (FSGS) on histopathology, that often leads to chronic kidney failure.Objective. This study determined the urinary concentrations of β-2-microglobulin (β2M) and cystatin C proteins in children with HIVANand primary FSGS.Methods. The study group comprised 34 children; 14 with HIVAN and 20 with primary FSGS. The control groups were 20 HIV-positiveand 20 HIV-negative children with no kidney disease. Urine samples collected from these 74 children were stored at -80°C. Bio-Plextechnology was used to analyse the urinary protein concentration of cystatin C and β2M.Results. A significant increase in urinary β2M levels was observed in the HIVAN group compared with the HIV-negative group(p=0.0240). No other statistically significant differences in urinary β2M concentrations were noted across the study groups. Urinarycystatin C levels were significantly increased in primary FSGS children compared with both HIV-negative (p=0.0041) and HIV-positivecontrols (p=0.0256). Urinary cystatin C displayed a significant increase in the primary FSGS compared with the HIVAN group (p=0.0150).No significant differences in urinary cystatin C levels were noted in the HIVAN group compared with the HIV-negative and HIV-positivecontrol groups.Conclusion. Urinary cystatin C has promising prognostic value to predict primary FSGS from HIVAN.
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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
21
审稿时长
12 weeks
期刊最新文献
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