{"title":"新型Revolver仪器在罗匹尼罗缓释片生物相关溶出度测定中的应用","authors":"Bartłomiej Milanowski, Mateusz Kuprianowicz","doi":"10.33320/maced.pharm.bull.2023.69.03.118","DOIUrl":null,"url":null,"abstract":"Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo predictions (IVIVP). A recently developed Revolver apparatus (Fig. 1) allows mimicking the acceptor fluid composition and flow as well as pH changes occurring in the human fasted intestine. This work presents and showcases the first application of the Revolver in dissolution testing of SR tablets with ropinirole hydrochloride (RH).","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"40 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of a novel Revolver apparatus for a biorelevant dissolution test of ropinirole sustained release tablets\",\"authors\":\"Bartłomiej Milanowski, Mateusz Kuprianowicz\",\"doi\":\"10.33320/maced.pharm.bull.2023.69.03.118\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo predictions (IVIVP). A recently developed Revolver apparatus (Fig. 1) allows mimicking the acceptor fluid composition and flow as well as pH changes occurring in the human fasted intestine. This work presents and showcases the first application of the Revolver in dissolution testing of SR tablets with ropinirole hydrochloride (RH).\",\"PeriodicalId\":30550,\"journal\":{\"name\":\"Makedonsko Farmacevtski Bilten\",\"volume\":\"40 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Makedonsko Farmacevtski Bilten\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.118\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Makedonsko Farmacevtski Bilten","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Application of a novel Revolver apparatus for a biorelevant dissolution test of ropinirole sustained release tablets
Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo predictions (IVIVP). A recently developed Revolver apparatus (Fig. 1) allows mimicking the acceptor fluid composition and flow as well as pH changes occurring in the human fasted intestine. This work presents and showcases the first application of the Revolver in dissolution testing of SR tablets with ropinirole hydrochloride (RH).
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