大麻油在明胶和阿拉伯胶中的微胶囊化及其在正己烷介质中累积释放特性的研究

Okan BAYRAM, Fethiye GÖDE
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引用次数: 0

摘要

本研究以大麻油为原料,采用复凝聚法制备明胶(GE)和阿拉伯胶(GA)聚合物微胶囊化。研究了响应面法(RSM)中选择的3个参数(搅拌转速1000.0 ~ 1500.0 rpm、温度50 ~ 60℃、表面活性剂浓度0.3 ~ 0.7 w/v%)对包封效率的影响。并在不同时间(1 min、3 min、5 min、7 min、10 min、30 min、60 min、120 min、240 min、360 min、720 min、1440 min、2160 min、2880 min)对其在正己烷中的释放特性进行研究。对微胶囊的释放结果进行检测,发现微胶囊开始时呈快速释放,随着时间的推移,释放值保持恒定。在特殊条件下,用光学显微镜和扫描电子显微镜(SEM)对所得微胶囊进行检测。光学显微镜下观察到微胶囊光滑圆润。
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Microencapsulation of Hemp Oil in Gelatin and Gum Arabic and Investigation of Cumulative Release Properties in n-Hexane Medium
In this study, hemp oil was microencapsulated with gelatin (GE) and gum arabic (GA) polymers by complex coacervation method. The effects of three parameters (stirring speed 1000.0–1500.0 rpm, temperature 50–60 °C, surfactant concentration 0.3–0.7 w/v%) selected in the response surface methodology (RSM) on the encapsulation efficiency were investigated. The obtained results were maximized by multiple response prediction, and the release characteristics were investigated in n-hexane at different times (1 min, 3 min, 5 min, 7 min, 10 min, 30 min, 60 min, 120 min, 240 min, 360 min, 720 min, 1440 min, 2160 min, 2880 min). When the release results were examined, it was observed that the microcapsules started with a rapid release, and the release value remained constant as time progressed. Obtained microcapsules were examined under optical microscope and scanning electron microscope (SEM) devices under special conditions. The microcapsules were observed to be smooth and round in shape under the optical microscope.
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
81
审稿时长
5 weeks
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