{"title":"SETD2缺乏通过氧化应激和fasl介导的细胞凋亡促进炎症性肠病","authors":"Yueduo Wang, Shenghai Shen, Haorui Zhu","doi":"10.26502/fjhs.141","DOIUrl":null,"url":null,"abstract":"Background: SET-domain-containing 2 (SETD2) is known as the only trimethyltransferase for regulating histone H3 lysine 36 (H3K36) methylation, being involved in the generation and development of many diseases. Although SETD2 has been found to modulate oxidative stress in the intestinal epithelial tissue of inflammatory bowel disease (IBD) samples, the specific functions of SETD2 in IBD development are yet to be fully understood.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SETD2 Deficiency Promotes Inflammatory Bowel Disease via Oxidative Stress and FasL-Mediated Apoptosis\",\"authors\":\"Yueduo Wang, Shenghai Shen, Haorui Zhu\",\"doi\":\"10.26502/fjhs.141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: SET-domain-containing 2 (SETD2) is known as the only trimethyltransferase for regulating histone H3 lysine 36 (H3K36) methylation, being involved in the generation and development of many diseases. Although SETD2 has been found to modulate oxidative stress in the intestinal epithelial tissue of inflammatory bowel disease (IBD) samples, the specific functions of SETD2 in IBD development are yet to be fully understood.\",\"PeriodicalId\":73052,\"journal\":{\"name\":\"Fortune journal of health sciences\",\"volume\":\"24 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fortune journal of health sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26502/fjhs.141\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fortune journal of health sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26502/fjhs.141","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SETD2 Deficiency Promotes Inflammatory Bowel Disease via Oxidative Stress and FasL-Mediated Apoptosis
Background: SET-domain-containing 2 (SETD2) is known as the only trimethyltransferase for regulating histone H3 lysine 36 (H3K36) methylation, being involved in the generation and development of many diseases. Although SETD2 has been found to modulate oxidative stress in the intestinal epithelial tissue of inflammatory bowel disease (IBD) samples, the specific functions of SETD2 in IBD development are yet to be fully understood.
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