Fatemeh Beigloo, Samira Amiri Khoshkar-Vandi, Elham Pourmand, Mona Heydari, Fatemeh Molaabasi, Nima Gharib, Yasser Zare, Kyong Yop Rhee, Soo-Jin Park
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Electrochemical micro- and nanobiosensors for in vivo reactive oxygen/nitrogen species measurement in the brain
Abstract In this focused review, we examine the influence of reactive oxygen and nitrogen species (ROS/RNS) on physiological processes and the induction of oxidative stress, with particular emphasis on the brain and neuronal systems. We discuss the formation mechanisms of ROS and RNS, their significance in the brain, and various detection methods. The review investigates the latest advancements in nano-engineered electrochemical biosensors designed for in vivo monitoring of ROS and RNS in the brain tissue. We explore the electrochemical measurement of specific species, such as H 2 O 2 , superoxide, NO, and peroxynitrite, while providing a comparative evaluation of sensor designs for ROS and RNS detection in the brain. Finally, we offer an outlook and conclusion on the future of this field.
期刊介绍：
The bimonthly journal Nanotechnology Reviews provides a platform for scientists and engineers of all involved disciplines to exchange important recent research on fundamental as well as applied aspects. While expert reviews provide a state of the art assessment on a specific topic, research highlight contributions present most recent and novel findings.
In addition to technical contributions, Nanotechnology Reviews publishes articles on implications of nanotechnology for society, environment, education, intellectual property, industry, and politics.
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