致幻剂和营养药物干预作为军事相关轻度创伤性脑损伤的治疗策略

IF 0.7 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Military, Veteran and Family Health Pub Date : 2023-10-25 DOI:10.3138/jmvfh-2022-0084
Amy C. Reichelt, Eric Vermetten, Benjamin T. Dunkley
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引用次数: 0

摘要

脑震荡是一种获得性脑损伤,在军队、平民和接触性运动运动员中很常见,被定义为一种短暂的精神功能损伤。然而,脑震荡带来了相当大的健康负担,少数人遭受持续损伤。反复的次震荡性头部损伤是神经退行性疾病(包括痴呆)的已知危险因素。脑震荡很难治疗,因为症状各不相同,但迷幻疗法可能有助于解决脑损伤后出现的一些神经问题。经典的迷幻药有望成为一种新兴的药物干预手段,因为它们似乎能帮助大脑重新连接,并具有抗炎作用。营养药物干预措施广泛可用,成本效益高,耐受性好,并且当与迷幻化合物联合使用时,它们也可以支持康复。在这里,研究提出了经典致幻剂和营养保健品可能与致幻剂联合作为治疗脑震荡和持续性症状的治疗策略进行了讨论。
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Psychedelic and nutraceutical interventions as therapeutic strategies for military-related mild traumatic brain injuries
LAY SUMMARY Concussion is a type of acquired brain injury that is common in the military, as well as among civilians and contact sport athletes, and is defined by a transient impairment in mental function. Nevertheless, concussion presents a considerable health burden, and a small minority of people suffer from continued impairment. Repetitive sub-concussive head injury is a known risk factor for neurodegenerative disease, including dementias. Concussions are difficult to treat because symptom profiles vary, but psychedelic therapies may help address some of the neurological issues that occur after brain injury. Classic psychedelics show promise as an emerging pharmacological intervention because they appear to help the brain to rewire, and they have anti-inflammatory effects. Nutraceutical interventions are widely available, cost-effective, and well tolerated, and they could also support recovery when combined with psychedelic compounds. Here, studies presenting classical psychedelics and nutraceuticals that may be combined with psychedelics as therapeutic strategies for the treatment of concussions and persistent symptoms are discussed.
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CiteScore
1.60
自引率
11.10%
发文量
72
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