{"title":"基于生物可降解聚合物的纳米药物递送系统用于妇科恶性肿瘤的治疗","authors":"Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao","doi":"10.1080/00914037.2023.2263133","DOIUrl":null,"url":null,"abstract":"AbstractGynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.Keywords: Biodegradable polymersdrug-delivery systemgynecological malignancynanoparticles Additional informationFundingThis work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).","PeriodicalId":14203,"journal":{"name":"International Journal of Polymeric Materials and Polymeric Biomaterials","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies\",\"authors\":\"Keer Jin, Hanxue Zhang, Yuwei Yang, Yan Gao\",\"doi\":\"10.1080/00914037.2023.2263133\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"AbstractGynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.Keywords: Biodegradable polymersdrug-delivery systemgynecological malignancynanoparticles Additional informationFundingThis work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).\",\"PeriodicalId\":14203,\"journal\":{\"name\":\"International Journal of Polymeric Materials and Polymeric Biomaterials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2023-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Polymeric Materials and Polymeric Biomaterials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/00914037.2023.2263133\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Polymeric Materials and Polymeric Biomaterials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/00914037.2023.2263133","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Nano-drug delivery systems based on biodegradable polymers for the therapy of gynecological malignancies
AbstractGynecological malignancies are the main factors that seriously endanger the life and health of women worldwide. Chemotherapy is one of the traditional methods for the treatment of gynecological malignancies. Conventional chemotherapeutic drugs used in medicine have shortcomings, such as poor target tissue-specific distribution, high toxicity, and side effects. They are prone to problems such as tumor recurrence, invasion, metastasis, and drug resistance. The rapid development of nano-drug delivery systems achieves attenuation, potentiation, inhibition of metastasis, and resistance to drug resistance, bringing hope for the treatment of gynecological malignancies. This article briefly summarizes novel nano-drug delivery systems based on biodegradable polymers and their mediated treatment strategy for gynecological tumors to provide a theoretical basis for developing and clinically translating nano-drug delivery systems for gynecological malignancies.Keywords: Biodegradable polymersdrug-delivery systemgynecological malignancynanoparticles Additional informationFundingThis work was sponsored by the Natural Science Foundation of Liaoning Province (2020-ZLLH-41).
期刊介绍:
International Journal of Polymeric Materials and Polymeric Biomaterials is the official publication of the International Society for Biomedical Polymers and Polymeric Biomaterials (ISBPPB). This journal provides a forum for the publication of peer-reviewed, English language articles and select reviews on all aspects of polymeric materials and biomedical polymers. Being interdisciplinary in nature, this journal publishes extensive contributions in the areas of encapsulation and controlled release technologies to address innovation needs as well.