多发性硬化不良病程的临床标志

Mariya S. Matrosova, Galina N. Belskaya, Vasiliy V. Bryukhov, Ekaterina V. Popova, Marina V. Krotenkova
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摘要

目标。研究与多发性硬化症不良病程及其向进行性亚型转变相关的可能临床标志物。 材料和方法。这项前瞻性研究包括健康志愿者和复发-缓解型多发性硬化症(RRMS)、继发性进行性多发性硬化症(SPMS)、原发性进行性多发性硬化症(PPMS)患者。为了进行全面的临床评估,参与者完成了25英尺步行测试(T25-FW)、九孔钉测试(9-HPT)、符号数字模式测试(SDMT)、疲劳测试和MSProDiscuss问卷调查。然后比较各组结果。 结果。我们发现,在大多数测试中,两组之间存在显著差异。此外,我们提出了基于T25-FW、SDMT和9-HPT结果的综合临床评分(CCS)(双手)。 讨论。我们的CCS是一种有用的临床工具,可以在某个时间点确定多发性硬化症最可能的病程。
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Clinical markers for unfavorable course of multiple sclerosis
Objective. To study possible clinical markers associated with the unfavorable course of multiple sclerosis and its transition to a progressive subtype. Materials and methods. This prospective study included healthy volunteers and patients with relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS), primary progressive multiple sclerosis (PPMS). For a comprehensive clinical evaluation, the participants completed the Timed 25-Foot Walk Test (T25-FW), Nine-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT), Fatigue test, and MSProDiscuss questionnaires. Then we compared the results between the groups. Results. We found significant differences between the groups in regard to most of the tests. Furthermore, we proposed a composite clinical score (CCS) based on T25-FW, SDMT, and 9-HPT results (for both hands). Discussion. Our CCS can be a useful clinical tool to determine the most likely course of multiple sclerosis at a certain timepoint.
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来源期刊
Annals of Clinical and Experimental Neurology
Annals of Clinical and Experimental Neurology Medicine-Neurology (clinical)
CiteScore
0.80
自引率
0.00%
发文量
32
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