Osmidrosis lotion affect ApoD and ABCC11 mRNA levels in axillary osmidrosis patients

Purpose: To investigate the potential role of osmidrosis lotion in alleviating axillary osmidrosis (AO).Methods: Forty patients were randomly divided into four groups (n = 10). Patients were treated via topical application of Lithargyrum, Sophora flavescens Alt., or Cortex dictamni, or osmidrosis lotion, for 40 min over a three-month period. Total skin RNA was extracted from samples using TRIzol while total platelet RNA was treated with DNase I, followed by quantification using NanoDrop and Agilent 2100 Bioanalyzer.Results: Lithargyrum, Sophora flavescens Alt. and Cortex dictamni significantly inhibited the mRNA expressions of ApoD and ABCC11 in AO patients (p < 0.05). Furthermore, osmidrosis lotion produced the best down-regulating effect on mRNA expressions of ApoD and ABCC11 in AO patients.Conclusion: The suppressive effect of these natural remedies may be beneficial in the development of non-surgical therapy for AO and therefore would be worth further investigation.