不同类型脓皮病中中性粒细胞胞外捕获器的存在

IF 1.1 Q4 ALLERGY Journal of Cutaneous Immunology and Allergy Pub Date : 2023-10-24 DOI:10.1002/cia2.12331

Takaharu Ikeda MD, PhD, Tamihiro Kawakami MD, PhD, Kae Yokoyama MD, Yuka Nishibata PhD, Sakiko Masuda PhD, Utano Tomaru MD, PhD, Akihiro Ishizu MD, PhD

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摘要

我们通过观察 MPO 和 Cit H3 蛋白免疫标记的扩展和密集区域，发现在各种类型的脓疱疮（PG）皮肤活检组织中存在大量的中性粒细胞胞外陷阱（NET）。我们认为，在绝大多数特发性脓疱疮患者的皮损中，中性粒细胞可能会形成异常的 NET。在一名抗磷脂综合征患者的皮肤溃疡中，我们没有检测到与典型溃疡性 PG 相似的 NET，而在各种类型的 PG 中却发现了丰富的 NET。这些研究结果表明，皮肤组织中NET的存在可作为鉴别诊断各种类型PG和其他类似疾病的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The presence of neutrophil extracellular traps in different forms of pyoderma gangrenosum

We demonstrated that there were abundant neutrophil extracellular traps (NETs) in the skin biopsies from various types of pyoderma gangrenosum (PG), based on the observation of extended and compact areas of immunolabeling of MPO and Cit H3 proteins. We suggest that neutrophils could undergo an aberrant NET formation in the lesions of PG patients, in the vast majority of idiopathic PG. We did not detect NETs in the skin ulcers of an antiphospholipid syndrome patient with a similar appearance to classical ulcerative PG, while rich NETs were found in the various types of PG. These findings suggest that the presence of NETs in skin tissues could serve as a marker for making differential diagnoses of various types of PG from other similar conditions.

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