Utilidad clínica de la versión española de la Clinically Useful Depression Outcome Scale (CUDOS) para determinar los síntomas de respuesta precoz en pacientes diagnosticados de trastornos del ánimo

Objective: to analyse the usefulness in clinical practice of the CUDOS scale (Clinically Useful Depression Outcome Scale) to assess depressive symptomatology and identify early remission symptoms. Methods: a descriptive longitudinal prospective multicentre study in >18-year-old persons diagnosed with “mood disorder”. The validated versions of CUDOS and EQ-Decentering (the higher the decentering, the lower the depressive symptomatology) were used for data collection; age, gender, level of education, occupational status, civil status, clinical diagnosis and comorbidities were also collected. Multiple regression analysis was conducted with those variables which appeared clinically significant. Finally, the Area under the ROC Curve was calculated, in order to understand the overall performance of the CUDOS scale. Results: the study included 175 patients; almost 60% of the sample suffered Major Depressive Disorder. The initial mean score in CUDOS was 44.5. The factors predicting early remission identified by Logistic Regression Analysis at Day 4 after admission were: “I thought of a hopeless future” and “I can separate my thoughts and feelings from myself” (EQ-Decentering). The ROC curve analysis showed an Area under the ROC Curve of 0.84. Conclusions: CUDOS is a tool sensitive to change within short periods of time. The cognitive area items are the first to change during depression improvement. Pessimism regarding the future and the ability for defusion regarding thought and feelings allow to predict who will improve in their next assessment.